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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo

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Author(s):
Silva, Adriana R. [1] ; de Lacerda, Jose T. J. G. [2] ; Faria, Bernadete [2] ; da Cunha, Isabela W. [3] ; de Andrade, Vitor P. [3] ; Assuncao, Nilson A. [2, 1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-04039032 Diadema, SP - Brazil
[2] Univ Fed Sao Paulo, Escola Paulista Med, BR-04023062 Sao Paulo, SP - Brazil
[3] AC Camargo Canc Ctr, Dept Patol, BR-01509010 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 29, n. 2, p. 363-370, FEB 2018.
Web of Science Citations: 0
Abstract

Old age is a risk factor for cancer development in humans and animals, and studies have shown that tumors in animals are acceptable models for studying human cancers, considering the similarities between their factors. This work was conducted in a 53-year-old captive female common hippo (Hippopotamus amphibious) with a left leg tumor and metastatic mass. Histopathological and immunohistochemical analyses were carried out with a final diagnosis of a high grade pleomorphic sarcoma. A proteomic study using mass spectrometry was added in order to identify further aspects of the primary tumor and metastasis which could improve our understanding, and each tissue showed a proteomic profile indicative of its pathologic state with significant differences between healthy tissue, primary and metastatic tumors. Low levels of beta-actin in primary tumors were identified, and this may be associated with a possible consequence of cytoskeleton dynamic modification. In metastatic tissue, these dynamics may be affected by the presence of HSP chaperone 60. (AU)

FAPESP's process: 12/02514-9 - Use of proteomics techniques to study radical acetylation of proteins triggered by products of the reaction biacetyl/peroxinitrite
Grantee:Nilson Antonio de Assunção
Support Opportunities: Regular Research Grants