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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Maternal Hypercholesterolemia Associated with Nicotine Exposure in Adulthood May Induce Kidney Injury in Male Rats if Hypomagnesemia Occurs

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Author(s):
Helou, Claudia M. B. [1] ; Volpini, Rildo A. [1] ; Santinho, Mirela A. R. [1] ; Fonseca, Fabricio L. [1] ; Simiao, Andre L. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Lab Pesquisa Basica LIM 12, Nefrol, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Kidney & Blood Pressure Research; v. 42, n. 6, p. 974-982, 2017.
Web of Science Citations: 0
Abstract

Background/Aims: Maternal hypercholesterolemia is a risk factor to renal injury in rat pups at adulthood, especially if they feed a cholesterol-enriched diet after weaning. However, the renal function of male pups of dams with hypercholesterolemia (PH) that were fed a regular chow from weaning to adulthood needs investigation, particularly those exposed to an adverse risk such as nicotine. Methods: We evaluated the renal function of PH animals and we compared the data with those found in male pups of control dams (PC) at 3- and 6-month-old by inulin clearance. Moreover, we investigated the effect of nicotine treatment for 8 days in both PH and PC animals at 6 months old via metabolic function studies and by renal histological analysis. Results: Inulin clearance and other renal function parameters were similar in PH and PC animals at 3 and 6 months old. Nevertheless, the PH group showed significant differences with regard to histological analysis despite a similar number of glomeruli. The glomerular area of PH animals was significantly smaller than that measured in PC animals, and the fractional interstitial area was significantly larger in PH animals than that measured in PC animals at 3 months old. With regard to nicotine treatment, we observed a trend for a reduction in creatinine clearance in both PC and PH groups, but only PH animals showed hypomagnesemia and the highest fractional interstitial area. Conclusions: The offspring exposed to a high cholesterol milieu during intrauterine and neonatal life may show a silent kidney injury at adulthood that may be aggravated by nicotine exposure if hypomagnesemia occurs. (c) 2017 The Author(s) Published by S. Karger AG, Basel (AU)

FAPESP's process: 10/52294-0 - Assessing the role of vitamin D in the development of postischemic acute kidney injury
Grantee:Rildo Aparecido Volpini
Support Opportunities: Regular Research Grants