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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Changes in the inspiratory pattern contribute to modulate the sympathetic activity in sino-aortic denervated rats

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Author(s):
Amorim, Mateus R. [1] ; Bonagamba, Leni G. H. [1] ; Souza, George M. P. R. [1] ; Moraes, Davi J. A. [1] ; Machado, Benedito H. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Experimental Physiology; v. 102, n. 9, p. 1100-1117, SEP 1 2017.
Web of Science Citations: 5
Abstract

The activity of presympathetic neurons is under respiratory modulation, and changes in the central respiratory network may impact on the baseline sympathetic activity and mean arterial pressure. It is well known that after removal of baroreceptor afferents {[}sino-aortic denervation (SAD)], rats present an unexpected normal level of mean arterial pressure. We hypothesized that changes in the respiratory pattern and in the respiratory modulation of the sympathetic activity contribute to keep the sympathetic outflow within a normal range of variation in the absence of arterial baroreceptors in rats. To study these mechanisms, we recorded perfusion pressure and the activities of phrenic and thoracic sympathetic nerves in male juvenile rats using the working heart-brainstem preparation. The time of inspiration significantly increased in SAD rats, and this change was not dependent on the carotid bodies or on the vagal afferents. However, no changes were observed in the perfusion pressure or in the baseline thoracic sympathetic nerves in all phases of the respiratory cycle in SAD rats. Our data show that despite longer inspiratory activity, the baseline sympathetic activity is maintained at a normal level in SAD rats. These findings indicate that the respiratory-sympathetic coupling is normal after SAD and suggest that the respiratory modulation of sympathetic activity is maintained within the normal range after the removal of arterial baroreceptors. (AU)

FAPESP's process: 13/06077-5 - Changes in the neural networks involved with the generation and control of sympathetic and respiratory activities in different experimental models of hypoxia
Grantee:Benedito Honorio Machado
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/15195-1 - Electrophysiological characterization of respiratory and presympathetic neurons in the rostral ventrolateral medulla after sinoaortic denervation in rats
Grantee:Mateus Ramos Amorim
Support Opportunities: Scholarships in Brazil - Doctorate