History of vascular reactivity models and their involvement in hypertension pathogenesis

Author(s)

Conceicao-Vertamatti, Ana Gabriela ^[1] ; Borghi, Filipy ^[1] ; Canova, Fernando ^[1] ; Grassi-Kassisse, Dora Maria ^[1]

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Lab Stress Study, Dept Struct & Funct Biol, Inst Biol, Campinas, SP - Brazil

• Document type: Review article
• Source: Vasa-European Journal of Vascular Medicine; v. 46, n. 6, p. 431-439, OCT 2017.
• Web of Science Citations: 3

Abstract

Hypertension is a silent and multifactorial disease. Over two centuries ago, the first device to record blood pressure was developed, making it possible to determine normotension and to establish criteria for hypertension. Since then, several studies have contributed to advance knowledge in this area, promoting significant advances in pharmacological treatments and, as a result, increasing survival of hypertensive people. The main models developed for the study of hypertension and the main findings in the vascular area are included in this review. We considered aspects related to vascular reactivity, changes in the population, and action of beta adrenergic receptors in the pathogenesis of hypertension. (AU)

• FAPESP's process: 06/53266-4 - Chemistry, photochemistry and biological applications of ruthenium complexes with nitric oxide and related species. From solution to materials
• Grantee: Elia Tfouni
• Support Opportunities: Research Projects - Thematic Grants