| Grant number: | 06/53266-4 |
| Support Opportunities: | Research Projects - Thematic Grants |
| Start date: | May 01, 2008 |
| End date: | October 31, 2012 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry |
| Principal Investigator: | Elia Tfouni |
| Grantee: | Elia Tfouni |
| Host Institution: | Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| City of the host institution: | Ribeirão Preto |
| Principal investigators | Alzir Azevedo Batista ; Douglas Wagner Franco ; Roberto Santana da Silva |
| Associated scholarship(s): | 10/10674-0 - Evaluation of the ability to prevent restenosis and endothelialization promotion through biological activity of new materials eluting nitric oxide,
BP.PD 08/09935-4 - Biological activity of ruthenium complexes as Nitric oxide donor agents in neoplasic cell lines. Chemical, photochemical and citotoxic aspects, BP.DR |
Abstract
This proposal focuses on the chemical and/or photochemical release of NO and the reactivity of complexes involving nitric oxide (NO) and related species such as nitrite and nitroxyl. Previous studies have concentrated on fundamental aspects of synthesis and chemical and photochemical reactivities of ruthenium nitrosyls, with some studies on their biological activity. Highlights of the present proposal include a deeper investigation of previously studied fundamental issues, such as: studies of reactions of nucleophilic attack of hydroxide ion on coordinated nitrosyls in ruthenium complexes with NO; photochemical studies directed to mechanistic aspects; development of complexes able to release NO with irradiation with light of the red region of the spectrum, and, thus, potentially useful in photodynamic therapy (PDT); along with other issues which are detailed in the proposal. Other important aspect worth to mention is the study of immobilized complexes, in the search for NO donors’ materials, directly or via nitrite to NO conversion, taking into account that nitrita is present in mammalian species. Other highlight of the proposal is the study of complexes involving other biologically important species, the nitroxyl ion (NO-), a very recent issue that needs investigation. All systems of these topics were conceived having in mind potential biological applications of the synthesized complexes. The proposal also aims at specific and controlled NO delivery, since NO can be either benefitial or harmful, depending on its concentration. Thus, specificity and delivery control are important factors taken into consideration in the design of the studied and proposed systems. As a result of work done so far, it can be noticed in the present proposal a large percentage of studies with potential biological applications, such as, for example, Chagas disease, Leishmaniosis, aorta rings relaxation, and anti-tumor activity. (AU)
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