Synthesis, characterization and thermal reactivity and photochemistry of ruthenium complexes: implications in catalysis, chemotherapy and photodynamic therapy

• Grant number: 92/03515-3
• Support Opportunities: Research Projects - Thematic Grants
• Start date: December 01, 1993
• End date: November 30, 1998
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Douglas Wagner Franco
• Grantee: Douglas Wagner Franco
• Host Institution: Instituto de Física e Química de São Carlos (IFQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated research grant(s): 98/10757-0 - Peter C. Ford | University of California - Estados Unidos, AV.EXT; 98/06764-0 - Modulation of the release of no by the p(oet)3 trans effect in trans-[ru(nh3)4p(oet)3no]x3., AR.EXT; 97/06804-0 - Bruce Ritchie McGarvey | University of Windsor - Canadá, AV.EXT; + associated grants 97/06755-9 - Crystal structure and chemical properties of the trans-[ru(nh3)4(h2o)no]cl3.h2o., AR.EXT; 97/03906-6 - Morton Z. Hoffman | Boston University - Estados Unidos, AV.EXT; 96/03204-9 - Ruthenium (ii) complexes with hemilabile ligands., AR.EXT; 96/01928-0 - Michael J. Clarke | Boston College - United States, AV.EXT; 95/09034-5 - Photochemical behavior of carbonyl complexes of ruthenium (ii) ammines., AR.EXT; 95/03163-8 - Alfred Beverly Philip Lever | York University - Canada, AV.EXT - associated grants

Abstract

Nitric oxide is of considerable interest because of its environmental effects, its use in catalysis and its important role in many biological processes. Despite its thermodynamic instability, no is kinetically inert with respect to decomposition and reduction and requires the presence of metal or metal oxides for many of its reactions. In these systems the no reactivity is markedly influence by the metal center coordination sphere characteristics. Therefore, on principle the thermal and photochemical reactivities of the nitrosyl ligand could be controlled by tailoring the metal center coordination sphere. Aiming to learn more about the mutual influences of the ancilary ligands and no upon their respective reactivities a systematic study was proposed using ruthenium complexes as models. at the begining we start with ruthenium ammines Trans-[Ru(Nh3)4nox]N+, (X = N-Heterocyclic Ligand, So3=, P(Or)3, P(R)3; moving to polydentate ligands as edta, cyclam, and polyphosphanes. the work deals with synthesis, characterization, photochemical and thermal reactivities, catalytic tests, biological tests and modeling of these nitrosyl complexes.. during our investigation electrochemistry (C.V., D.P.P.), resonance (NMR, EPR) vibrational (Ir, RAMAN) and electronicc (UV-Vis) spestroscopies are used as routine. our aim is to contribute to the understanding of the no activation through coordination, accordingly to the tailoring of new and better catalysts, and pharmaceuticals. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SIQUEIRA, MARCOS RECHI; PERRONE, OLAVO MICALI; METZKER, GUSTAVO; DE OLIVEIRA LISBOA, DANIELA CORREA; THOMEO, JOAO CLAUDIO; BOSCOLO, MAURICIO. Highly selective 1-butanol obtained from ethanol catalyzed by mixed metal oxides: Reaction optimization and catalyst structure behavior. MOLECULAR CATALYSIS, v. 476, OCT 2019. (16/15575-7, 17/13230-5, 92/03515-3, 15/11588-4, 13/23886-4)

METZKER, GUSTAVO; VARGAS, JORGE ANDRES MORA; DE LIMA, LIVIA PADILHA; PERRONE, OLAVO MICALI; SIQUEIRA, MARCOS RECHI; VARANDA, LAUDEMIR CARLOS; BOSCOLO, MAURICIO. First row transition metals on the ethanol Guerbet reaction: Products distribution and structural behavior of mixed metal oxides as catalysts. APPLIED CATALYSIS A-GENERAL, v. 623, AUG 5 2021. (92/03515-3, 20/02471-4, 19/11058-6, 17/09520-8)