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Nitrosyl and nitroxyl as ligands on Ru(II): synthesis, kinetics, reactivity and thermodynamics

Grant number: 12/23651-4
Support Opportunities:Regular Research Grants
Duration: March 01, 2013 - February 28, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Douglas Wagner Franco
Grantee:Douglas Wagner Franco
Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil


The present research project presents a natural extension of previous ones including HNO/NO- system. The reactivity aspects still enclosed in the present project. The knowledge regarding to the reactivity changes on the phosphorus esters coordinated to ruthenium can provide a better understanding of its reactivity and help on tailoring more robust compounds with respect to nucleophilic attack enabling its application as metallopharmaceutical platform. Similarly, the reactions between the nitrosyl complex and the RSH / RSSR system will help to better understand the activation aspects of these compounds in biological medium and the reactivity of these molecules. Indeed, this proposition is not limited to fundamental aspects, but also exhibit implications on the metallodrugs development area. The ligand activation through coordination, already successfully tested with the benznidazole, observing an increase on the activity due to a facilitation of its reduction will now be extended to nitrocompounds. In this case, however, it is desired a decrease on the reducing potential of the ligand inducing selectivity and reducing the toxicity. With respect to the HNO/NO- system, efforts will be directed towards developing the fundamental chemistry using a similar approach used for the nitrosyl systems. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROVEDA, JR., ANTONIO CARLOS; AGUIAR, HELENA DE FAZIO; MIRANDA, KATRINA M.; TADINI, CARMEN CECILIA; FRANCO, DOUGLAS WAGNER. Light-triggered and cysteine-mediated nitric oxide release from a biodegradable starch-based film. JOURNAL OF MATERIALS CHEMISTRY B, v. 2, n. 41, p. 7232-7242, . (12/23651-4)
FREITAS, CRISTINA S.; ROVEDA, ANTONIO C.; TRUZZI, JR., DANIELA R.; GARCIA, ANDRE C.; CUNHA, THIAGO M.; CUNHA, FERNANDO Q.; FRANCO, DOUGLAS W.. Anti-inflammatory and Anti-nociceptive Activity of Ruthenium Complexes with Isonicotinic and Nicotinic Acids (Niacin) as Ligands. Journal of Medicinal Chemistry, v. 58, n. 11, p. 4439-4448, . (12/23651-4, 13/08216-2, 11/19670-0)
TRUZZI, DANIELA R.; CASTELLANO, EDUARDO E.; FRANCO, DOUGLAS W.. Synthesis, characterization, X-ray crystallography and stability in aqueous medium of trans-[Ru(CO)(NH3)(4)P(OH)(3)](2+). Polyhedron, v. 124, p. 184-190, . (12/23651-4)
SOUZA, MAYKON L.; CASTELLANO, EDUARDO E.; TELSER, JOSHUA; FRANCO, DOUGLAS W.. Secondary Coordination Sphere Effects in Ruthenium(III) Tetraammine Complexes: Role of the Coordinated Water Molecule. Inorganic Chemistry, v. 54, n. 4, p. 2067-2080, . (12/23651-4)
ROVEDA JR, ANTONIO C.; SANTOS, WILLY G.; SOUZA, MAYKON L.; ADELSON, CHARLES N.; GONCALVES, FELIPE S.; CASTELLANO, EDUARDO E.; GARINO, CLAUDIO; FRANCO, DOUGLAS W.; CARDOSO, DANIEL R.. Light-activated generation of nitric oxide (NO) and sulfite anion radicals (SO3 center dot-) from a ruthenium(II)nitrosylsulphito complex. DALTON TRANSACTIONS, v. 48, n. 29, p. 10812-10823, . (12/23651-4, 17/01189-0)
AGUIAR, HELENA DE FAZIO; ROVEDA JUNIOR, ANTONIO CARLOS; PIVA, RENAN DE JESUS; ONODA, KEVIN AKIRA; MIYAKAWA, AYUMI AUREA; KRIEGER, JOSE EDUARDO; FRANCO, DOUGLAS WAGNER; TADINI, CARMEN CECILIA. Compatibility of Cassava Starch Films as Nitric Oxide Carrier for Potential Medical Device. Journal of Applied Polymer Science, v. 132, n. 2, . (12/23651-4, 13/17368-0, 10/16057-3)
SOUZA, MAYKON LIMA; ROVEDA, JR., ANTONIO CARLOS; MELO PEREIRA, JOSE CLAYSTON; FRANCO, DOUGLAS WAGNER. New perspectives on the reactions of metal nitrosyls with thiolates as nucleophiles. Coordination Chemistry Reviews, v. 306, n. 2, SI, p. 615-627, . (12/23651-4)

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