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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Circulating levels of the angiogenesis mediators endoglin, HB-EGF, BMP-9 and FGF-2 in patients with severe sepsis and septic shock

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Author(s):
Faiotto, Vanessa Boury [1] ; Franci, Daniel [1] ; Enz Hubert, Rodolfo Monteiro [1] ; de Souza, Gleice Regina [1] ; Luz Fiusa, Maiara Marx [1] ; Hounkpe, Bidossessi Wilfried [1] ; Santos, Thiago Martins [1] ; Carvalho-Filho, Marco Antonio [1] ; De Paula, Erich Vinicius [2, 1]
Total Authors: 9
Affiliation:
[1] Univ Estadual Campinas, Sch Med Sci, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF CRITICAL CARE; v. 42, p. 162-167, DEC 2017.
Web of Science Citations: 1
Abstract

Purpose: Endothelial barrier dysfunction is a hallmark of sepsis, and is at least partially mediated by pathways that regulate endothelial barrier assembly during angiogenesis. Not surprisingly, increased levels of key angiogenic proteins such as VEGF-A and Angiopoietin-2 have been described in sepsis. The purpose of this study was to investigate if additional pathways that regulate endothelial barrier integrity during angiogenesis could also be involved in the host response of sepsis. Material and methods: We evaluated circulating levels of four proteins involved in angiogenesis, not previously studied in sepsis, in a cohort of 50 patients with severe sepsis and septic shock. Results: Circulating levels of BMP-9 and FGF-2 were similar in patients and healthy volunteers. In contrast, patients with septic shock presented 1.5-fold higher levels of endoglin (P=0.004), and 2-fold lower levels of Heparin-Binding EGF-like growth factor (HB-EGF) (P=0.002) when compared to healthy individuals. Of note, HB-EGF deficiency has been recently demonstrated to be detrimental to survival in a murine model of sepsis. Conclusions: Endoglin and HB-EGF could be involved in the host response of sepsis. Additional studies are warrant to investigate their role as biomarker or therapeutic targets in sepsis. (c) 2017 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 13/09319-0 - Exploration of new mechanisms of epithelial barrier brekdown in acute gastrintestinal graft-versus-host-disease associated with alterations in "tight junctions"
Grantee:Erich Vinicius de Paula
Support Opportunities: Regular Research Grants