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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The origin of prostate gland-secreted IgA and IgG

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Author(s):
Silva, Juliete A. F. [1] ; Biancardi, Manoel F. [1, 2] ; Stach-Machado, Dagmar R. [1] ; Reis, Leonardo O. [3] ; Sant'Anna, Osvaldo A. [4] ; Carvalho, Hernandes F. [5, 1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Dept Struct & Funct Biol, Campinas, SP - Brazil
[2] Univ Fed Goias, Dept Histol Embriol & Cell Biol, Goiania, Go - Brazil
[3] Pontificial Univ Campinas, Ctr Life Sci, Campinas, SP - Brazil
[4] Butantan Inst, Dept Immunochem, Sao Paulo - Brazil
[5] Natl Inst Sci & Technol Photon Appl Cell Biol INF, Campinas, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 7, NOV 28 2017.
Web of Science Citations: 0
Abstract

The prostate secretes immunoglobulin (Ig) A (IgA) and IgG; however, how immunoglobulins reach the secretion, where the plasma cells are located, whether immunoglobulins are antigen-specific and where activation of the adaptive response occurs are still unknown. Immune cells, including CD45RA(+) cells, were scattered in the stroma and not organized mucosae-associated lymphoid-tissue. IgA (but not IgG) immunostaining identified stromal plasma cells and epithelial cells in non-immunized rats. Injected tetramethylrhodamine-IgA transcytosed the epithelium along with polymeric immunoglobulin receptor. Oral immunization with ovalbumin/mesopourous SBA-15 silica adjuvant resulted in more stromal CD45RA(+)/IgA(+) cells, increased content of ovalbumin-specific IgA and IgG, and the appearance of intraepithelial CD45RA(+)/IgG(+) cells. An increased number of dendritic cells that cooperate in other sites with transient immunocompetent lymphocytes, and the higher levels of interleukin-1 beta, interferon-gamma and transforming growth factor-beta, explain the levels of specific antibodies. Nasal immunization produced similar results except for the increase in dendritic cells. This immunomodulatory strategy seems useful to boost immunity against genitourinary infections and, perhaps, cancer. (AU)

FAPESP's process: 13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling
Grantee:Hugo Aguirre Armelin
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 09/16150-6 - Androgen regulation, sinalization and cellular interactions in prostate development, physiology and regression
Grantee:Hernandes Faustino de Carvalho
Support Opportunities: Research Projects - Thematic Grants