Is there a place for dexmedetomidine in equine anaesthesia and analgesia? A systematic review (2005-2017)

Author(s)

Gozalo-Marcilla, M. ^[1] ; Gasthuys, F. ^[2] ; Luna, S. P. L. ^[1] ; Schauvliege, S. ^[2]

Affiliation

^[1] Sao Paulo State Univ UNESP, Dept Vet Surg & Anaesthesiol, Sch Vet Med & Anim Sci, Botucatu, SP - Brazil

^[2] Univ Ghent, Dept Surg & Anaesthesia Domest Anim, Fac Vet Med, Merelbeke - Belgium

• Document type: Review article
• Source: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; v. 41, n. 2, p. 205-217, APR 2018.
• Web of Science Citations: 5

Abstract

The objective of this review was to perform a literature compilation of all the equine publications that used dexmedetomidine as the first article on this topic was published, in 2005. We also aimed to answer the question whether the use of dexmedetomidine can currently be justified. For that, we compiled information from databases, such as PubMed, Google Scholar and Web of Science and the proceedings of the last veterinary anaesthesiology meetings. Dexmedetomidine is an attractive drug to be used in horses, mainly due to its pharmacokinetic profile and pharmacodynamics that favour its use as intravenous constant rate infusion (CRI). Nowadays, its clinical use is popular for sedation in prolonged standing procedures and during partial intravenous anaesthesia (PIVA) and total intravenous anaesthesia (TIVA). However, legal requirements for its use should be taken into account. (AU)

• FAPESP's process: 17/01425-6 - Clinical application of different constant rate infusions of detomidine and methadone in standing horses
• Grantee: Miguel Gozalo Marcilla
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 14/00474-5 - Antinociceptive effects and farmacokinetics in horses treated with different low doses of methadone and detomidine
• Grantee: Miguel Gozalo Marcilla
• Support Opportunities: Scholarships in Brazil - Post-Doctoral