| Full text | |
| Author(s): Show less - |
Jurmeister, Sarah
[1]
;
Ramos-Montoya, Antonio
[1]
;
Sandi, Chiranjeevi
[1]
;
Pertega-Gomes, Nelma
[2]
;
Wadhwa, Karan
[1]
;
Lamb, Alastair D.
[3, 1, 4]
;
Dunning, Mark J.
[5]
;
Attig, Jan
[6, 7]
;
Carroll, Jason S.
[8]
;
Fryer, Lee G. D.
[1]
;
Felisbino, Sergio L.
[9]
;
Neal, David E.
[3, 1, 4]
Total Authors: 12
|
| Affiliation: | [1] CRUK Cambridge Inst, Urooncol Res Grp, Cambridge - England
[2] Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA - USA
[3] Univ Cambridge, Dept Urol, Cambridge - England
[4] Addenbrookes Hosp, Dept Oncol, Cambridge - England
[5] CRUK Cambridge Inst, Bioinformat Core Facil, Cambridge - England
[6] UCL, Dept Mol Neurosci, Inst Neurol, London - England
[7] MRC Lab Mol Biol, Cambridge - England
[8] Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge - England
[9] Sao Paulo State Univ UNESP, Dept Morphol, Inst Biosci Botucatu, Sao Paulo - Brazil
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | EMBO MOLECULAR MEDICINE; v. 10, n. 3 MAR 2018. |
| Web of Science Citations: | 11 |
| Abstract | |
Genetically engineered mouse models of cancer can be used to filter genome-wide expression datasets generated from human tumours and to identify gene expression alterations that are functionally important to cancer development and progression. In this study, we have generated RNAseq data from tumours arising in two established mouse models of prostate cancer, PB-Cre/Pten(loxP/loxP) and p53(loxP/loxP)Rb(loxP/loxP), and integrated this with published human prostate cancer expression data to pinpoint cancer-associated gene expression changes that are conserved between the two species. To identify potential therapeutic targets, we then filtered this information for genes that are either known or predicted to be druggable. Using thisapproach, we revealed a functional role for the kinase MELK as a driver and potential therapeutic target in prostate cancer. We found that MELK expression was required for cell survival, affected the expression of genes associated with prostate cancer progression and was associated with biochemical recurrence. (AU) | |
| FAPESP's process: | 13/08830-2 - Progression and metastasis of prostate cancer in epithelium conditional PTEN-/- or pRb-/-p53-/- deficient mice (Cre/loxP): proliferation and oxidative stress markers |
| Grantee: | Sérgio Luis Felisbino |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/06802-1 - Progression and metastasis of prostate cancer in conditional PTEN-/- or pRb-/-p53-/- deficient mice (Cre/loxP): proliferation and oxidative stress markers |
| Grantee: | Sérgio Luis Felisbino |
| Support Opportunities: | Scholarships abroad - Research |