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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Enhanced angiotensin II induced sodium appetite in renovascular hypertensive rats

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Author(s):
Roncari, Camila F. [1, 2] ; Barbosa, Rafaela M. [1] ; Vendramini, Regina C. [3] ; De Luca, Jr., Laurival A. [1] ; Menani, Jose V. [1] ; Colombari, Eduardo [1] ; Colombari, Debora S. A. [1]
Total Authors: 7
Affiliation:
[1] UNESP, Sao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Araraquara, SP - Brazil
[2] Univ Fed Ceara, Sch Med, Dept Physiol & Pharmacol, Fortaleza, CE - Brazil
[3] UNESP, Sao Paulo State Univ, Sch Pharm, Dept Clin Anal, Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Peptides; v. 101, p. 82-88, MAR 2018.
Web of Science Citations: 2
Abstract

Renovascular hypertensive 2-kidney, 1-clip (2K1C) rats have an increased activity of the renin-angiotensin system and an initial transitory increase in daily water and NaCl intake. However, the dipsogenic and natriorexigenic responses to angiotensin II (ANG II) have not been tested yet in 2K1C rats. Therefore, in the present study, we evaluated water and 0.3M NaCl intake induced by water deprivation (WD)-partial rehydration (PR) or intracerebroventricular (icv) ANG II in 2K1C rats. In addition, the cardiovascular changes to these treatments were also evaluated. Male Holtzman rats received a silver clip around the left renal artery to induce 2K1C renovascular hypertension. In the 5th week, a group of animals received a guide cannula in the lateral ventricle for icv injections. Daily water intake increased from the 3rd week after surgery and remained elevated until the 6th week (last recording week), whereas daily 0.3M NaCl intake transiently increased from the 2nd to the 5th week after surgery. On the 6th week, in spite of comparable daily 0.3M NaCl intake between 2K1C and sham rats, WD-PR and icv ANG II induced an increased 0.3M NaCl intake in 2K1C rats. Water intake induced by WDPR, not by icv ANG II, also increased in 2K1C rats. The increase in arterial pressure to WD-PR or icv ANG II was similar in sham and 2K1C rats. Therefore, these results suggest that 2K1C rats are more responsive to the natriorexigenic effects of ANG II, whereas other responses to ANG II are not modified. (AU)

FAPESP's process: 15/23467-7 - Experimental pathophysiology: role of central mechanisms of the cardiovascular and respiratory control changes induced by experimental hypertension and obesity
Grantee:Eduardo Colombari
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 11/50770-1 - Neural mechanisms involved of hydroelectrolytic balance and cardiorespiratory control
Grantee:José Vanderlei Menani
Support Opportunities: Research Projects - Thematic Grants