Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone

Author(s)

da Silva, Rodrigo M. ^[1] ; Guaratini, Thais ^[2] ; Jimenez, Paula C. ^[3] ; Fenical, William ^[4] ; Costa-Lotufo, Leticia V. ^[5] ; Vessecchi, Ricardo ^[6] ; Lopes, Norberto P. ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, NPPNS, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Lychnoflora Pesquisa & Desenvolvimento Prod Nat L, Campus USP, BR-14030090 Ribeirao Preto, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Ciencias Mar, BR-11070100 Santos, SP - Brazil

^[4] Univ Calif San Diego, Scripps Inst Oceanog, CMBB, 9500 Gilman Dr 0204, La Jolla, CA 92093 - USA

^[5] Univ Sao Paulo, Dept Farmacol, Inst Ciencias Biomed, BR-05508900 Sao Paulo, SP - Brazil

^[6] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 29, n. 5, p. 1162-1166, MAY 2018.
• Web of Science Citations: 1

Abstract

Seriniquinone is a natural quinone isolated from a rare marine bacterium of the genus Serinicoccus. This secondary metabolite has been shown to have anticancer properties, which has raised attention of the scientific community. In this short report, we present the first investigation of the gas-phase chemistry fragmentation reactions of seriniquinone in electrospray ionization tandem mass spectrometry (ESI-MS/MS), to be further applied in pharmacokinetics and metabolism studies. All the proposals herein were supported by computational chemistry. (AU)

• FAPESP's process: 14/50265-3 - Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation
• Grantee: Norberto Peporine Lopes
• Support type: BIOTA-FAPESP Program - Thematic Grants