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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Direct, Metal-free C(sp(2))-H Chalcogenation of Indoles and Imidazopyridines with Dichalcogenides Catalysed by KIO3

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Author(s):
Rafique, Jamal [1] ; Saba, Sumbal [1] ; Franco, Marcelo S. [1] ; Bettanin, Luana [1] ; Schneider, Alex R. [1] ; Silva, Lais T. [1] ; Braga, Antonio L. [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CHEMISTRY-A EUROPEAN JOURNAL; v. 24, n. 16, p. 4173-4180, MAR 15 2018.
Web of Science Citations: 34
Abstract

Herein, we report a greener protocol for the synthesis of 3-Se/S-indoles and imidazo{[}1,2-a]pyridines through direct C(sp(2))-H bond chalcogenation of heteroarenes with half molar equivalents of different dichalcogenides, using KIO3 as a non-toxic, easy-to-handle catalyst and a stoichio-metric amount of glycerol. The reaction features are high yields, based on atom economy, easy performance on gramscale, metal-and solvent-free conditions as well as applicability to different types of N-heteroarenes. (AU)

FAPESP's process: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
Grantee:Arlene Gonçalves Corrêa
Support Opportunities: Research Grants - Research Centers in Engineering Program