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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Is it possible to use Forensic DNA phenotyping in Brazilian population?

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Fridman, Cintia [1] ; Siria Godoy Cardena, Mari Maki [1] ; Lima, Felicia de Araujo [1] ; Goncalves, Fernanda de Toledo [1]
Total Authors: 4
[1] Univ Sao Paulo, Sch Med, Dept Legal Med Eth & Occupat Hlth, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Web of Science Citations: 2

The prediction of human traits in order to help forensic investigations has been one of the most interesting researches in the last decade. Some pigmentation genes such as SLC45A2 variants have been associated with phenotypic diversity of skin, eyes and hair color in homogeneous populations. The aim of this study was evaluate the possibility of association between three SLC45A2 polymorphisms (rs26722, rs16891982 and 2,278,007) with skin, eye and hair color in a sample of 598 individuals of admixed population from Brazil, intending to use it in forensic genetic situations. DNA sequencing was performed with BigDye Terminator v3.1 and capillary electrophoresis was performed in ABI3130. Presence of rs16891982 variant (C>G) was associated with non-black skin (OR 16.35; CI 6.014-44.5), as well as with non-black hair (OR 18.12. CI 5.25-62.6) and light eyes (OR 5.04; CI 2.6-9.6). Polymorphism rs2278007 in heterozygous (AG) was associated with a lower probability of individual presenting lighter pigmentation of skin and hair. Our data corroborates the findings of other studies in homogeneous populations, suggesting that the analysis of SLC45A2 polymorphisms can be used as a tool to access some phenotypic traits and use to help forensic identifications as molecular predictor of phenotypes also in admixed populations. These results supplement the previous ones we showed in the same population with the genes SLC24A5 and ASIP, and they are part of major project, which aims to study the correlation of several pigmentation genes and skin, hair and eye color in Brazilian population. (C) 2015 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 12/02043-6 - Prediction of complex phenotypes such as skin, eyes and hair color from genotypic analyzes for forensic purposes
Grantee:Cintia Fridman Rave
Support Opportunities: Regular Research Grants