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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Osteoinductive porous biphasic calcium phosphate ceramic as an alternative to autogenous bone grafting in the treatment of mandibular bone critical-size defects

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Author(s):
Santos, Paula Sanches [1] ; Cestari, Tania Mary [1] ; Paulin, Jessica Botto [1] ; Martins, Renato [1] ; Rocha, Caroline Andrade [1] ; Nunes Arantes, Ricardo Vinicius [1] ; Costa, Bruna Carolina [2] ; dos Santos, Cassio Morilla [2] ; Assis, Gerson Francisco [1] ; Taga, Rumio [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Bauru Dent Sch, Dept Biol Sci, BR-17012901 Sao Paulo - Brazil
[2] Sao Paulo State Univ, UNESP, Adv Mat Lab, Dept Phys, BR-17033360 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 106, n. 4, p. 1546-1557, MAY 2018.
Web of Science Citations: 6
Abstract

The bone-induction capacity of a porous biphasic calcium phosphate (pBCP) using heterotopic implantation in mouse (mHI-model) and its efficacy as substitute for autograft in mandibular critical-size defect in rabbit (rabMCSD-model) was investigated. In mHI-model, pBCP was implanted into the thigh muscles and bone formation was histomorphometrically and immunohistochemically evaluated. In rabMCSD-model, 13 mm bone defects were treated with pBCP or autograft and bone repair comparatively evaluated by radiographic and histomorphometric methods. In mHI-model, formed bone and immunolabeling for bone morphogenetic protein-2 and osteopontin were observed in 90% of pBCP implanted samples after 12 weeks. In rabMCSD-model neither statistically significant difference was found in newly formed bone between pBCP and autograft groups at 4 weeks (18.8 +/- 5.5% vs 27.1 +/- 5.6%), 8 weeks (22.3 +/- 2.7% vs 26.2 +/- 5.1), and 12 weeks (19.6 +/- 4.7% vs 19.6 +/- 2.3%). At 12 weeks, the stability and contour of the mandible were restored in both treatments. Near tooth remaining, pBCP particles were covered by small amount of mineralized tissue exhibiting perpendicular attachments of collagen fiber bundles with histological characteristic of acellular cementum. Within the limitations of this study, it was concluded that pBCP is osteoinductive and able to stimulate the new formation of bone and cementum-like tissues in rabMCSD-model, suggesting that it may be an alternative to treatment of large bone defect and in periodontal regenerative therapy. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1546-1557, 2018. (AU)

FAPESP's process: 11/10902-6 - Evaluation of the osteoinductive capacity of the ceramic HA/TCP porous in the ratio 70:30 when implanted surgically between the muscle fascia of mice and rats
Grantee:Jéssica Botto Paulin
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 11/11157-2 - Comparative evaluation of the bone repair process of rabbit mandibular defect treated with biphasic ceramic HA/beta-TCP 70:30 in particles and autogenous graft
Grantee:Paula Sanches dos Santos
Support Opportunities: Scholarships in Brazil - Scientific Initiation