Controlled release of an optically active compound by hydrogels of acrylic acid and its online detection

Author(s)

Aguiar, Leandro G. ^[1] ; Iwakura, Daniel C. ^{[2, 3]} ; Semeano, Ana T. S. ^[2] ; Li, Rosamaria W. C. ^{[2, 4]} ; Souza, Esmar F. ^[3] ; Gruber, Jonas ^[2] ; Giudici, Reinaldo ^[3]

Affiliation

^[1] Univ Sao Paulo, Dept Engn Quim, Escola Engn Lorena, Estr Municipal Campinho S-N, BR-12602810 Lorena, SP - Brazil

^[2] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Escola Politecn, Dept Engn Quim, Av Prof Luciano Gualberto, Trav 3, 380, BR-05508900 Sao Paulo, SP - Brazil

^[4] Ctr Univ Estacio Radial Sao Paulo, Campus Vila Remedios, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: CANADIAN JOURNAL OF CHEMICAL ENGINEERING; v. 96, n. 5, p. 1221-1227, MAY 2018.
• Web of Science Citations: 2

Abstract

Hydrogels of acrylic acid were produced through solution free radical polymerization at 70 degrees C. The materials obtained were put in contact with D-fructose solution and the swelling behaviour was registered. The swollen hydrogels were immersed in distilled water and the D-fructose released was quantified in real time by a low-cost polarized light optoelectronic detection system. A simplified mathematical model was developed in order to represent the system under study. This model was tested against experimental data, showing good agreement. Additionally, the effect of the model parameters on the prediction profiles was evaluated. (AU)

• FAPESP's process: 12/11532-0 - Synthesis and characterization of hydrogels of poly(acrylic acid): mathematical modeling and applications in controlled drug release
• Grantee: Leandro Gonçalves de Aguiar
• Support Opportunities: Scholarships in Brazil - Post-Doctoral