| Full text | |
| Author(s): |
Malta, Tathiane M.
[1, 2]
;
de Souza, Camila F.
[1, 2]
;
Sabedot, Thais S.
[1, 2]
;
Silva, Tiago C.
[1]
;
Mosella, Maritza S.
[1]
;
Kalkanis, Steven N.
[2]
;
Snyder, James
[2, 3]
;
Castro, Ana Valeria B.
[2]
;
Noushmehr, Houtan
[1, 2]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Genet, Sao Paulo - Brazil
[2] Henry Ford Hosp, Dept Neurosurg, 2799 West Grand Blvd, Detroit, MI 48202 - USA
[3] Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 - USA
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | NEURO-ONCOLOGY; v. 20, n. 5, p. 608-620, MAY 2018. |
| Web of Science Citations: | 19 |
| Abstract | |
Gliomas are a heterogeneous group of brain tumors with distinct biological and clinical properties. Despite advances in surgical techniques and clinical regimens, treatment of high-grade glioma remains challenging and carries dismal rates of therapeutic success and overall survival. Challenges include the molecular complexity of gliomas, as well as inconsistencies in histopathological grading, resulting in an inaccurate prediction of disease progression and failure in the use of standard therapy. The updated 2016 World Health Organization (WHO) classification of tumors of the central nervous system reflects a refinement of tumor diagnostics by integrating the genotypic and phenotypic features, thereby narrowing the defined subgroups. The new classification recommends molecular diagnosis of isocitrate dehydrogenase (IDH) mutational status in gliomas. IDH-mutant gliomas manifest the cytosine-phosphate-guanine (CpG) island methylator phenotype (G-CIMP). Notably, the recent identification of clinically relevant subsets of G-CIMP tumors (G-CIMP-high and G-CIMP-low) provides a further refinement in glioma classification that is independent of grade and histology. This scheme may be useful for predicting patient outcome and may be translated into effective therapeutic strategies tailored to each patient. In this review, we highlight the evolution of our understanding of the G-CIMP subsets and how recent advances in characterizing the genome and epigenome of gliomas may influence future basic and translational research. (AU) | |
| FAPESP's process: | 16/06488-3 - Integrative epigenomic analysis of high and low Glioma-CpG island Methylator Phenotype (G-CIMP): characterization and methods development |
| Grantee: | Thaís Sarraf Sabedot |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 16/15485-8 - Clinical biomarkers in central nervous system tumors |
| Grantee: | Camila Ferreira de Souza |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 14/08321-3 - Identification and characterization of functional genomic elements associated with progression of low to high grade glioma: integrative study of genome and epigenome |
| Grantee: | Camila Ferreira de Souza |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/12329-5 - Chromatin accessibility and DNA methylation changes associated with high and low Glioma-CpG island methylator phenotype (G-CIMP) |
| Grantee: | Thaís Sarraf Sabedot |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |
| FAPESP's process: | 16/10436-9 - Development and enhancement of bioinformatic tools to integrate and understand aberrant epigenomic and genomic changes associated with cancer: methods, development and analysis |
| Grantee: | Tiago Chedraoui Silva |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |
| FAPESP's process: | 15/07925-5 - Open source software statistical tools to aid in analyzing and integrating large cancer epigenomic datasets in order to decipher and understand regulatory networks |
| Grantee: | Houtan Noushmehr |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/01975-3 - Defining stem cell epigenomic signatures in 33 different tumor types across 9000+ tumor samples |
| Grantee: | Tathiane Maistro Malta Pereira |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 14/02245-3 - Identification of epigenomic signatures that define open chromatin regulatory networks associated with mesenchymal differentiation from human pluripotent stem cells |
| Grantee: | Tathiane Maistro Malta Pereira |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/01389-7 - Bioinformatic tool to integrate and understand aberrant epigenomic and genomic changes associated with cancer: methods, development and analysis |
| Grantee: | Tiago Chedraoui Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 16/11039-3 - Charting Epigenomic Signatures in CpG Island Methylator Phenotype (CIMP) Tumors |
| Grantee: | Maritza Queiroz Salas Mosella |
| Support Opportunities: | Scholarships in Brazil - Doctorate |