| Full text | |
| Author(s): Show less - |
Pedroso, Joao A. B.
[1]
;
de Mendonca, Pedro O. R.
[2]
;
Fortes, Marco A. S.
[1]
;
Tomaz, Igor
[1]
;
Pecorali, Vitor L.
[1]
;
Auricino, Thais B.
[2]
;
Costa, Ismael C.
[2]
;
Lima, Leandro B.
[1]
;
Furigo, Isadora C.
[1]
;
Bueno, Debora N.
[1]
;
Ramos-Lobo, Angela M.
[1]
;
Lotfi, Claudimara F. P.
[2]
;
Donato, Jr., Jose
[1]
Total Authors: 13
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Journal of Endocrinology; v. 235, n. 3, p. 207-222, DEC 2017. |
| Web of Science Citations: | 2 |
| Abstract | |
Many hormones/cytokines are secreted in response to exercise and cytokine signaling may play a pivotal role in the training adaptations. To investigate the importance of cytokine signaling during vertical ladder climbing, a resistance exercise model, we produced mice lacking SOCS3 protein exclusively in steroidogenic factor-1 (SF1) cells (SF1 Socs3 KO mice). SF1 expression is found in steroidogenic cells of the adrenal cortex and gonads, as well as in neurons of the ventromedial nucleus of the hypothalamus. Histological markers of the fetal adrenal zone (or X-zone in rodents) were still present in adult males and postpartum SF1 Socs3 KO females, suggesting a previously unrecognized effect of SOCS3 on the terminal differentiation of the adrenal gland. This change led to a distinct distribution of lipid droplets along the adrenal cortex. Under basal conditions, adult SF1 Socs3 KO mice exhibited similar adrenal weight, and plasma ACTH and corticosterone concentrations. Nonetheless, SF1 Socs3 KO mice exhibited a blunted ACTH-induced corticosterone secretion. The overall metabolic responses induced by resistance training remained unaffected in SF1 Socs3 KO mice, including changes in body adiposity, glucose tolerance and energy expenditure. However, training performance and glucose control during intense resistance exercise were impaired in SF1 Socs3 KO mice. Furthermore, a reduced counter-regulatory response to 2-deoxy-D-glucose was observed in mutant mice. These findings revealed a novel participation of SOCS3 regulating several endocrine and metabolic aspects. Therefore, cytokine signaling in SF1 cells exerts an important role to sustain training performance possibly by promoting the necessary metabolic adjustments during exercise. (AU) | |
| FAPESP's process: | 10/18086-0 - Molecular basis of leptin resistance |
| Grantee: | Jose Donato Junior |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 12/23535-4 - The role of POMC-derived peptides in differentiation and function of adrenal cortex |
| Grantee: | Pedro Omori Ribeiro de Mendonça |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/21722-4 - Mechanism of action of bromocriptine and prolactin antagonists in the treatment of Diabetes and Obesity |
| Grantee: | Isadora Clivatti Furigo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/11752-6 - Study of leptin functions during intrauterine and childhood stages in mice |
| Grantee: | Angela Maria Ramos Lobo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/50140-6 - Clams comprehensive Lab animal monitoring system |
| Grantee: | Jose Donato Junior |
| Support Opportunities: | Multi-user Equipment Program |
| FAPESP's process: | 15/10992-6 - Investigation of metabolic programming through different approaches |
| Grantee: | Jose Donato Junior |
| Support Opportunities: | Regular Research Grants |