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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

SOCS3 expression in SF1 cells regulates adrenal differentiation and exercise performance

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Author(s):
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Pedroso, Joao A. B. [1] ; de Mendonca, Pedro O. R. [2] ; Fortes, Marco A. S. [1] ; Tomaz, Igor [1] ; Pecorali, Vitor L. [1] ; Auricino, Thais B. [2] ; Costa, Ismael C. [2] ; Lima, Leandro B. [1] ; Furigo, Isadora C. [1] ; Bueno, Debora N. [1] ; Ramos-Lobo, Angela M. [1] ; Lotfi, Claudimara F. P. [2] ; Donato, Jr., Jose [1]
Total Authors: 13
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Endocrinology; v. 235, n. 3, p. 207-222, DEC 2017.
Web of Science Citations: 2
Abstract

Many hormones/cytokines are secreted in response to exercise and cytokine signaling may play a pivotal role in the training adaptations. To investigate the importance of cytokine signaling during vertical ladder climbing, a resistance exercise model, we produced mice lacking SOCS3 protein exclusively in steroidogenic factor-1 (SF1) cells (SF1 Socs3 KO mice). SF1 expression is found in steroidogenic cells of the adrenal cortex and gonads, as well as in neurons of the ventromedial nucleus of the hypothalamus. Histological markers of the fetal adrenal zone (or X-zone in rodents) were still present in adult males and postpartum SF1 Socs3 KO females, suggesting a previously unrecognized effect of SOCS3 on the terminal differentiation of the adrenal gland. This change led to a distinct distribution of lipid droplets along the adrenal cortex. Under basal conditions, adult SF1 Socs3 KO mice exhibited similar adrenal weight, and plasma ACTH and corticosterone concentrations. Nonetheless, SF1 Socs3 KO mice exhibited a blunted ACTH-induced corticosterone secretion. The overall metabolic responses induced by resistance training remained unaffected in SF1 Socs3 KO mice, including changes in body adiposity, glucose tolerance and energy expenditure. However, training performance and glucose control during intense resistance exercise were impaired in SF1 Socs3 KO mice. Furthermore, a reduced counter-regulatory response to 2-deoxy-D-glucose was observed in mutant mice. These findings revealed a novel participation of SOCS3 regulating several endocrine and metabolic aspects. Therefore, cytokine signaling in SF1 cells exerts an important role to sustain training performance possibly by promoting the necessary metabolic adjustments during exercise. (AU)

FAPESP's process: 10/18086-0 - Molecular basis of leptin resistance
Grantee:Jose Donato Junior
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 12/23535-4 - The role of POMC-derived peptides in differentiation and function of adrenal cortex
Grantee:Pedro Omori Ribeiro de Mendonça
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/21722-4 - Mechanism of action of bromocriptine and prolactin antagonists in the treatment of Diabetes and Obesity
Grantee:Isadora Clivatti Furigo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/11752-6 - Study of leptin functions during intrauterine and childhood stages in mice
Grantee:Angela Maria Ramos Lobo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/50140-6 - Clams comprehensive Lab animal monitoring system
Grantee:Jose Donato Junior
Support Opportunities: Multi-user Equipment Program
FAPESP's process: 15/10992-6 - Investigation of metabolic programming through different approaches
Grantee:Jose Donato Junior
Support Opportunities: Regular Research Grants