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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ER alpha in Skene's paraurethral gland of pubertal and adult gerbils

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Ribeiro, Naiara C. S. [1] ; Campos, Monica S. [2] ; Santos, Mariana B. [3] ; Ayusso, Gabriela M. [3] ; Vilamaior, Patricia S. L. [2] ; Regasini, Luis O. [3] ; Taboga, Sebastiao R. [2] ; Biancardi, Manoel F. [1] ; Perez, Ana P. S. [4] ; Santos, Fernanda C. A. [1]
Total Authors: 10
[1] Univ Fed Goias, Inst Biol Sci, Dept Histol Embryol & Cell Biol, Lab Histophysiol, Campus 2 Samambaia, BR-74001970 Goiania, Go - Brazil
[2] State Univ Sao Paulo, UNESP, Lab Microscopy & Microanal, Dept Biol, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[3] Sao Paulo State Univ, UNESP, Inst Biosci Humanities & Exact Sci Ibilce, Dept Chem & Environm Sci, Lab Green & Med Chem, Rua Cristovao Colombo 2265, Sao Jose Do Rio Preto, SP - Brazil
[4] Univ Fed Goias, Special Acad Unit Hlth Sci, Med Course, BR-75804020 Jatai, Go - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Fitoterapia; v. 124, p. 137-144, JAN 2018.
Web of Science Citations: 3

Chrysin is a plant-derived polyphenol that has the potential to increase endogenous testosterone levels both by inhibiting the aromatase enzyme and by stimulating testicular steroidogenesis. The effects of chrysin on the prostate are unknown, especially during its development and functional maturation. Thus, the aim of this study was to evaluate the effects of chrysin prepubertal exposure on the male and female prostates of both pubertal and adult gerbils. To evaluate the possible androgenic responses of chrysin, gerbils were also exposed to testosterone. Male and female gerbils were exposed to chrysin or to testosterone cypionate from postnatal day 15 to 42. Male and female gerbils were euthanized at either 43 days or 90 days age. The prostates were collected for biometrical, morphological and immunohistochemical analysis. The results showed that prepubertal exposure to chrysin had differential effects on the prostate of both pubertal and adult animals. The prostates of male and female pubertal gerbils showed no histological alterations, although there was increased frequency of androgen receptor (AR) in males and females, and estrogen receptor alpha (ER alpha) in females. Adult males and females presented developed prostate glands, with higher cell proliferative rate. In addition, AR and ER alpha frequency remained high in the prostate of adult animals. These results demonstrated that prepubertal exposure to chrysin disrupts steroid receptors regulation in the prostate, potentiating the response of this gland to the biological effects of endogenous steroids. In this context, excessive consumption of phytoestrogens during the critical stages of development should be considered with caution. (AU)

FAPESP's process: 14/18330-0 - Synthesis and biological evaluation of curcumin-cinnamaldehyde hybrids as bacterial cell division inhibitors
Grantee:Luis Octávio Regasini
Support type: Regular Research Grants