| Full text | |
| Author(s): |
Sá-Nunes, A.
;
Medeiros, A. I.
;
Jamur, M. C.
;
Oliver, C.
;
Dias-Baruffi, M.
;
Faccioli, L. H.
;
Bolzoni, R. M. F.
[7]
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Inflammation Research; v. 54, n. 6, p. 243-248, jun. 2005. |
| Field of knowledge: | Biological Sciences - Immunology |
| Abstract | |
This study examines the effect of ultrasonically nebulized distilled water inhalation on the systemic histamine hyperreactivity of Toxocara canis-infected mice. Uninfected and T. canis-infected mice received an intravenous sublethal dose of histamine and lethality rates were documented. At 24 days post infection, infected mice received ultrasonically nebulized distilled water inhalation for 1 h. Twenty-four hours later histamine levels were determined in bronchoalveolar lavage fluid as well as histamine lethality and toluidine blue-stained mast cell number in the lung. T. canis-infected mice showed increased lethality after exposure to histamine in comparison to uninfected mice. Ultrasonically nebulized distilled water inhalation prevented histamine-induced lethality and reduced toluidine blue-stained mast cell numbers in the lung. The correlation between decreases in stained mast cells in the lung after ultrasonically nebulized distilled water inhalation and inhibition of histamine-induced lethality in these animals suggests participation of mast cells in the phenomenon and could be helpful in understanding the mechanisms of hyperreactivity during helminth parasite infections. (AU) | |