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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Paroxetine and Fluoxetine Hexafluorosilicate salts: Synthesis, crystal structure, Hirshfeld surface, and supramolecular analysis

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Author(s):
Carvalho-, Jr., Paulo S. [1, 2] ; da Silva, Cecilia C. P. [1] ; Diniz, Luan F. [1] ; Souza, Matheus S. [1] ; Tenorio, Juan C. [1] ; Ellena, Javier [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Inst Fis Sao Carlos, CP 369, BR-13560970 Sao Carlos, SP - Brazil
[2] EMBRAPA Instrumentacao, Natl Nanotechnol Lab Agribusiness LNNA, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF FLUORINE CHEMISTRY; v. 209, p. 23-32, MAY 2018.
Web of Science Citations: 3
Abstract

Hexafluorosilicate salts of the antidepressant drugs Paroxetine (PRX) and Fluoxetine (FLX), {[}PRX](2)SiF6 and {[}FLX](2)SiF6 center dot H2O, are investigated herein by SCXRD, Hirshfeld surface analysis, and Infrared spectroscopy. By their crystal structures, it is possible to observe, for the first time, at least at the best of our knowledge, the formation of a supramolecular architecture of the (SiF6](2-) anion with protonated secondary amine groups. The {[}PRX](2)SiF6 crystallizes in the P2(1) space group and the {[}FLX](2)SiF6 center dot H2O in the P2(1)/c, as a hydrate racemate. While two conformers are present in the asymmetric unit of {[}PRX](2)SiF6, two enantiomers enclose the one of {[}FLX](2)SiF6 center dot H2O. Analysis of the crystal packing show that N-HF-Si (1.94-2.42 angstrom), C-HF-Si (2.36-2.62 angstrom), and C-Ha interactions are the main contributors toward the supramolecular architectures in these salts. (AU)

FAPESP's process: 12/05616-7 - Solid-state characterization of anticonvulsant and antidepressant phamaceutical compounds: Design of new crystal forms.
Grantee:Paulo de Sousa Carvalho Júnior
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/07581-9 - Design, Synthesis and Characterization of New Solid Forms of Anti-HIV Drugs.
Grantee:Juan Carlos Tenorio Clavijo
Support Opportunities: Scholarships in Brazil - Doctorate