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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Structure/Activity of PtII/N,N-Disubstituted-N'-acylthiourea Complexes: Anti-Tumor and Anti-Mycobacterium tuberculosis Activities

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Author(s):
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Ana M. Plutín [1] ; Anislay Alvarez [2] ; Raúl Mocelo [3] ; Raúl Ramos [4] ; Osmar C. Sánchez [5] ; Eduardo E. Castellano [6] ; Monize M. da Silva [7] ; Wilmer Villarreal [8] ; Legna Colina-Vegas [9] ; Fernando R. Pavan [10] ; Alzir A. Batista [11]
Total Authors: 11
Affiliation:
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[1] Universidad de La Habana. Facultad de Química. Laboratorio de Síntesis Orgánica - Cuba
[2] Universidad de La Habana. Facultad de Química. Laboratorio de Síntesis Orgánica - Cuba
[3] Universidad de La Habana. Facultad de Química. Laboratorio de Síntesis Orgánica - Cuba
[4] Universidad de La Habana. Facultad de Química. Laboratorio de Síntesis Orgánica - Cuba
[5] Universidad de La Habana. Facultad de Química. Laboratorio de Síntesis Orgánica - Cuba
[6] Universidade de São Paulo. Instituto de Física de São Carlos - Brasil
[7] Universidade Federal de São Carlos. Departamento de Química - Brasil
[8] Universidade Federal de São Carlos. Departamento de Química - Brasil
[9] Universidade Federal de São Carlos. Departamento de Química - Brasil
[10] Universidade Estadual Paulista. Faculdade de Ciências Farmacêuticas - Brasil
[11] Universidade Federal de São Carlos. Departamento de Química - Brasil
Total Affiliations: 11
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 29, n. 6, p. 1256-1267, 2018-06-00.
Abstract

The syntheses, characterization, cytotoxicity against tumor cells and anti-Mycobacterium tuberculosis activity assays of PtII/PPh3/N,N-disubstituted-N'-acylthioureas complexes with general formulae [Pt(PPh3)2(L)]PF6, PPh3 = triphenylphosphine; L = N,N-disubstituted-N'-acylthiourea, are here reported. The complexes were characterized by elemental analysis, molar conductivity, infrared (IR), nuclear magnetic resonance (NMR) (1H, 13C{1H} and 31P{1H}) spectroscopy. The 31P{1H} NMR data are consistent with the presence of two PPh3 ligands cis to each other position, and one N,N-disubstituted-N'-acylthiourea coordinated to the metal through O and S, in a chelate form. The structures of the complexes were determined by X-ray crystallography, forming distorted square-planar structures. The complexes were tested in human cell lines carcinomas and also screened with respect to their anti-Mycobacterium tuberculosis activity (H37RvATCC 27294). It was found that complexes with N,N-disubstituted-N'-acylthiourea containing open and small chains as R2 groups show higher cytotoxic and higher anti-Mycobacterium tuberculosis activity than those containing rings in this position. (AU)

FAPESP's process: 14/10516-7 - Search for ruthenium (II) complexes, with chemotherapeutic properties: evaluation of possible sinergistic effects and possible action mechanism
Grantee:Alzir Azevedo Batista
Support Opportunities: Regular Research Grants