| Full text | |
| Author(s): Show less - |
Torrealba, Marina Passos
[1]
;
Manfrere, Kelly Cristina
[1]
;
Miyashiro, Denis R.
[2]
;
Lima, Josenilson F.
[1]
;
Oliveira, Luana de M.
[1]
;
Pereira, Natalli Z.
[1]
;
Cury-Martins, Jade
[2]
;
Pereira, Juliana
[3]
;
Duarte, Alberto J. S.
[1]
;
Sato, Maria N.
[1]
;
Sanches, Jose A.
[2]
Total Authors: 11
|
| Affiliation: | [1] Univ Sao Paulo, Med Sch, Med Invest Lab LIM 56, Dept Dermatol, Trop Med Inst Sao Paulo, Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch, Dept Dermatol, Cutaneous Lymphoma Clin, Hosp Clin, Sao Paulo - Brazil
[3] Univ Sao Paulo, Med Sch, Hosp Clin, Hematol Dept, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | ONCOTARGET; v. 9, n. 3, p. 3497-3506, JAN 9 2018. |
| Web of Science Citations: | 2 |
| Abstract | |
Sezary syndrome (SS) is a leukemic variant of cutaneous T cell lymphoma (CTCL), and the neoplastic CD4+ T cells of SS patients undergo intense clonal proliferation. Although Sezary cells have been studied extensively, studies on adaptive immunity regarding CD8+ T cells are scarce. This study aimed to investigate activation marker expression in CD8+ T cells according to the differentiation stages and IL-7/IL7Ra axis responses of patients with SS. Moreover, this study aimed to verify the soluble forms of CD38, sCD127 and IL-7 in serum. Although the SS patients of our cohort had reduced numbers of CD8+ T cells, they exhibited higher percentages of CD8+CD38+T cells, mainly effector/memory CD8+ T cells, than the control group. In contrast, down-regulated expression of the activation markers CD127/IL-7R and CD26 was found in the CD8+ T cells of SS patients. High serum levels of sCD38 and sCD127 and scarce serum levels of IL-7 were detected, emphasizing the immune activation status of SS patients. Moreover, CD8+ T cells from SS patients exhibited IL-7 unresponsiveness to STAT5 phosphorylation and Bcl-2 expression, and IL-7 priming partially restored IFN gamma production. Our findings showed a chronic activation profile of CD8+ T cells, as an attenuated cytotoxic profile and impaired IL-7 responsiveness was observed, suggesting chronic activation status of CD8+ T cells in SS patients. (AU) | |
| FAPESP's process: | 14/04865-9 - Activation of cytotoxic response mediated by polyfunctional natural killer cells and t CD8+ cells induced by Toll-like-receptors agonists in the mycosis fungoides and Sézary syndrome |
| Grantee: | José Antonio Sanches Junior |
| Support Opportunities: | Regular Research Grants |