The hyperleptinemia state can downregulate cardiorespiratory fitness and energy expenditure in obese women

Author(s)

Sanches, Ricardo Badan ^{[1, 2]} ; Schoenardie Poli, Vanessa Fadanelli ^{[1, 2]} ; Novo Fidalgo, Joao Pedro ^{[1, 2]} ; Andrade-Silva, Stephan Garcia ^{[1, 2]} ; Cerrone, Leticia Andrade ^{[1, 2]} ; Oyama, Lila Missae ^[3] ; Damaso, Ana Raimunda ^{[4, 1, 2]} ; dos Santos, Ronaldo Thomatieli ^{[4, 1]} ; Caranti, Danielle Arisa ^{[4, 1, 2]}

Affiliation

^[1] Univ Fed Sao Paulo, UNIFESP, Post Grad Program Interdisciplinary Hlth Sci, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, UNIFESP, Obes Study Grp, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, UNIFESP, Dept Physiol, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, UNIFESP, Dept Biosci, Sao Paulo - Brazil

• Document type: Journal article
• Source: Physiology & Behavior; v. 184, p. 34-38, FEB 1 2018.
• Web of Science Citations: 0

Abstract

Introduction: In general, in obese people a state of hyperleptinemia may impair both energy balance and the inflammatory process. However, it has not been fully investigated whether there is a relationship between hyperleptinemia and cardiorespiratory fitness (CRF) and resting energy expenditure (REE), in obese women. Methods: 83 obese women were enrolled in this cross-sectional study. Anthropometric measures, body composition, REE, CRF and serum concentration of leptin were measured. Pearson's correlation coefficient was performed to examine the relationship between circulating leptin level and other clinical variables. Multiple regression analysis was applied to determine predictors of REE and CRF. Effects were considered significant at p <= 0.05. Results: The most important finding in the present study is that the hyperleptinemia state was inversely correlated with CRF (r = -0.382, p = 0.001) and REE (r = -0.447, p < 0.001). Moreover, a positive correlation with fat mass was confirmed (r = 0.419, p < 0.001). In addition, hyperleptinemia was an independent negative predictor of REE (r(2) = -2.649, p = 0.010) and CRF (r(2) = -2.335, p = 0.023). Conclusion: Together our results may suggest a vicious cycle between the state of hyperleptinemia and a decrease in energy expenditure and cardiorespiratory fitness in obese women, which can impair whole body energy homeostasis. This information is important to contribute to clinical practices. (AU)

• FAPESP's process: 11/51723-7 - Effects of interdisciplinary therapy on metabolic syndrome control in obese adults and its relationship with pro and anti inflammatory adipocytes
• Grantee: Danielle Arisa Caranti
• Support Opportunities: Regular Research Grants