Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27

Author(s):Show less -

Silva, Gabriel ^[1] ; Lima, Felipe Teixeira ^[1] ; Seba, Viviane ^[1] ; Mendes Lourenco, Ana Laura ^{[2, 1]} ; Lucas, Thaise Graminha ^{[2, 1]} ; de Andrade, Bianca Vieira ^{[2, 1]} ; Torrezan, Guilherme Silva ^[3] ; Polaquini, Carlos Roberto ^[3] ; Garcia, Marcelo Engracia ^[2] ; Couto, Lucelio Bernardes ^[2] ; Bestetti, Reinaldo Bulgarelli ^[2] ; Franca, Suzelei de Castro ^[1] ; Fachin, Ana Lucia ^{[2, 1]} ; Regasini, Luis Octavio ^[3] ; Marins, Mozart ^{[2, 1]}

Affiliation

^[1] Univ Ribeirao Preto, Biotechnol Unit, Av Costabile Romano 2201, BR-14096900 Ribeirao Preto, SP - Brazil

^[2] Univ Ribeirao Preto, Med Sch, Av Costabile Romano 2201, BR-14096900 Ribeirao Preto, SP - Brazil

^[3] Sao Paulo State Univ Unesp, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, Lab Green & Med Chem, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

• Document type: Journal article
• Source: Molecules; v. 23, n. 2 FEB 2018.
• Web of Science Citations: 6

Abstract

Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy. (AU)

• FAPESP's process: 14/15307-7 - Molecular analysis of the response of human and canine tumor strain lines to the flavonoid trans-chalcone
• Grantee: Mozart de Azevedo Marins
• Support type: Regular Research Grants
• FAPESP's process: 14/18330-0 - Synthesis and biological evaluation of curcumin-cinnamaldehyde hybrids as bacterial cell division inhibitors
• Grantee: Luis Octávio Regasini
• Support type: Regular Research Grants
• FAPESP's process: 17/03237-2 - Bioscreening of polyphenols with anticancer activity and investigation of the molecular mechanisms involving the p53 transcription factor
• Grantee: Mozart de Azevedo Marins
• Support type: Regular Research Grants