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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27

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Silva, Gabriel [1] ; Lima, Felipe Teixeira [1] ; Seba, Viviane [1] ; Mendes Lourenco, Ana Laura [2, 1] ; Lucas, Thaise Graminha [2, 1] ; de Andrade, Bianca Vieira [2, 1] ; Torrezan, Guilherme Silva [3] ; Polaquini, Carlos Roberto [3] ; Garcia, Marcelo Engracia [2] ; Couto, Lucelio Bernardes [2] ; Bestetti, Reinaldo Bulgarelli [2] ; Franca, Suzelei de Castro [1] ; Fachin, Ana Lucia [2, 1] ; Regasini, Luis Octavio [3] ; Marins, Mozart [2, 1]
Total Authors: 15
[1] Univ Ribeirao Preto, Biotechnol Unit, Av Costabile Romano 2201, BR-14096900 Ribeirao Preto, SP - Brazil
[2] Univ Ribeirao Preto, Med Sch, Av Costabile Romano 2201, BR-14096900 Ribeirao Preto, SP - Brazil
[3] Sao Paulo State Univ Unesp, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, Lab Green & Med Chem, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Molecules; v. 23, n. 2 FEB 2018.
Web of Science Citations: 6

Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy. (AU)

FAPESP's process: 14/15307-7 - Molecular analysis of the response of human and canine tumor strain lines to the flavonoid trans-chalcone
Grantee:Mozart de Azevedo Marins
Support type: Regular Research Grants
FAPESP's process: 14/18330-0 - Synthesis and biological evaluation of curcumin-cinnamaldehyde hybrids as bacterial cell division inhibitors
Grantee:Luis Octávio Regasini
Support type: Regular Research Grants
FAPESP's process: 17/03237-2 - Bioscreening of polyphenols with anticancer activity and investigation of the molecular mechanisms involving the p53 transcription factor
Grantee:Mozart de Azevedo Marins
Support type: Regular Research Grants