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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thyroid hormone improves insulin signaling and reduces the activation of neurodegenerative pathway in the hippocampus of diabetic adult male rats

Full text
Author(s):
Prieto-Almeida, Fernanda [1] ; Panveloski-Costa, Ana Carolina [1] ; Crunfli, Fernanda [1] ; Teixeira, Silvania da Silva [1] ; Nunes, Maria Tereza [1] ; Torrao, Andrea da Silva [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, Av Prof Lineu Prestes 1524, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Life Sciences; v. 192, p. 253-258, JAN 1 2018.
Web of Science Citations: 5
Abstract

Aims: Diabetes mellitus (DM) and impairments of glucose metabolism and insulin resistance in the brain have been suggested as a likely etiology of Alzheimer's disease (AD). Studies have shown that thyroid hormones (THs) improve insulin sensitivity in DM rats and act as mediators of the plasticity of the nervous system altering behavior and cognitive function. Based on these findings, this study aimed to evaluate the effects of diabetes and triiodothyronine (T3) treatment upon proteins associated with DM and AD in the central nervous system. Main methods: Euglycemic and Diabetic (alloxan-induced) male Wistar rats were daily treated with T3 (1.5 mu g/100 g body weight) or vehicle (saline) for a 4-week period and subdivided into the following groups: euglycemic treated with saline (Control = C); diabetic treated with saline (Diabetic = D); euglycemic treated with T3 (T3); diabetic treated with T3 (DT3). The expression of insulin signaling, neurodegenerative and neuron survival markers was evaluated in the hippocampus by immunoblotting, ELISA, and RT-PCR. Key findings: T3 treatment decreased glycemia, restored the insulin signaling and reduced the activation of glycogen synthase kinase 3 (GSK3) and tau proteins content in the hippocampus of diabetic rats. Significance: The present data provide evidence that T3 treatment of diabetic rats is able to improve insulin sensitivity and reduce the activation of the neurodegenerative pathway in the brain, which might provide neuroprotection in this experimental model. (AU)

FAPESP's process: 14/06372-0 - Mechanisms related to neurodegenerative diseases and the involvement of the cannabinoid system
Grantee:Andréa da Silva Torrão
Support Opportunities: Regular Research Grants
FAPESP's process: 14/15966-0 - The role of BDNF in the central nervous system associated with hyperthyroidism and diabetes mellitus
Grantee:Fernanda Prieto de Almeida
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 13/05629-4 - Genomic vs nongenomic actions of thyroid hormones: changes of paradigms, physiological implications and therapeutical perspectives
Grantee:Maria Tereza Nunes
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 10/18151-7 - Characterization of actions of TH and its agonist GC-1 in the homeostasis glycemic: study in muscle cells and diabetic rats
Grantee:Silvania da Silva Teixeira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 11/09014-9 - EFFECTS OF THYROID HORMONE IN MODULATING THE EXPRESSION OF CYTOKINES INVOLVED IN INSULIN SIGNALING DURING OBESITY OR DIABETES
Grantee:Ana Carolina Panveloski Costa Salomão
Support Opportunities: Scholarships in Brazil - Doctorate