Antimicrobial and Cytotoxic Activity of Dihydrobenzofuran Neolignans

Author(s)

Fukui, Murilo J. ^[1] ; Dias, Herbert J. ^[2] ; Severiano, Marcela E. ^[1] ; de Souza, Maria G. M. ^[1] ; de Oliveira, Pollyanna F. ^[1] ; Ambrosio, Sergio R. ^[1] ; Martins, Carlos H. G. ^[1] ; Tavares, Denise C. ^[1] ; Crotti, Antonio E. M. ^[2]

Affiliation

^[1] Univ Franca, Nucleo Pesquisa Ciencias Exatas & Tecnol, BR-14404600 Franca, SP - Brazil

^[2] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: CHEMISTRYSELECT; v. 3, n. 6, p. 1836-1839, FEB 14 2018.
• Web of Science Citations: 5

Abstract

We have evaluated the antimicrobial activity of the dihydrobenzofuran neolignans (DBNs) 1 ((+/-)-trans-dehydrodicoumarate dimethyl ester), 2 ((+/-)-trans-dehydrodiferulate dimethyl ester, 3 ((+/-)-4-O-acetyl-trans-dehydrodicoumarate dimethyl ester), and 4 ((+/-)-4-O-acetyl-trans-dehydrodiferulate dimethyl ester) in terms of their minimum inhibitory concentration (MIC) values. We have also assessed the cytotoxicity of compounds 1-4 to V79 cells by the XTT assay. Compounds 1, 2, and 3 display moderate activity against Streptococcus mitis (MIC = 400 g/ml); compound 2 is also active against Lactobacillus casei (MIC = 400 mu g/ml). Additionally, compound 3 is moderately active against Aspergillus niger (MIC = 125 mu g/ml), A. fumigatus (MIC = 500 mu g/ml), and Mucor rouxii (MIC = 250 mu g/ml). Compounds 2 and 4 (IC50 > 400 mu M), which have a methoxyl group at the aromatic ring, are less cytotoxic to V79 cells as compared to compounds 1 (IC50 = 232.00 +/- 7.33 mu M) and 3 (IC50 = 67.97 +/- 3.45 mu M). (AU)

• FAPESP's process: 13/20094-0 - Evaluation of the anti-parasitary and insecticidal activities of benzofuran derivatives, and study of their gas-phase fragmentation reactions using tandem mass spectrometry
• Grantee: Antônio Eduardo Miller Crotti
• Support Opportunities: Regular Research Grants
• FAPESP's process: 09/12202-1 - Antischistosomal and antileishmanial in vitro activities of some dihydrobenzofuran lignans
• Grantee: Murilo de Jesus Fukui
• Support Opportunities: Scholarships in Brazil - Master