Adipocytes role in the bone marrow niche

Author(s)

Guerra, Daniel A. P. ^[1] ; Paiva, Ana E. ^[1] ; Sena, Isadora F. G. ^[1] ; Azevedo, Patrick O. ^[1] ; Batista, Jr., Miguel Luiz ^[2] ; Mintz, Akiva ^[3] ; Birbrair, Alexander ^[1]

Affiliation

^[1] Univ Fed Minas Gerais, Dept Pathol, Belo Horizonte, MG - Brazil

^[2] Univ Mogi das Cruzes, Lab Adipose Tissue Biol, Sao Paulo - Brazil

^[3] Columbia Univ, Med Ctr, Dept Radiol, New York, NY - USA

• Document type: Letter
• Source: Cytometry Part A; v. 93A, n. 2, p. 167-171, FEB 2018.
• Web of Science Citations: 12

Abstract

Adipocyte infiltration in the bone marrow follows chemotherapy or irradiation. Previous studies indicate that bone marrow fat cells inhibit hematopoietic stem cell function. Recently, Zhou et al. (2017) using state-of-the-art techniques, including sophisticated Cre/loxP technologies, confocal microscopy, in vivo lineage-tracing, flow cytometry, and bone marrow transplantation, reveal that adipocytes promote hematopoietic recovery after irradiation. This study challenges the current view of adipocytes as negative regulators of the hematopoietic stem cells niche, and reopens the discussion about adipocytes' roles in the bone marrow. Strikingly, genetic deletion of stem cell factor specifically from adipocytes leads to deficiency in hematopoietic stem cells, and reduces animal survival after myeloablation, The emerging knowledge from this research will be important for the treatment of multiple hematologic disorders. (c) 2017 International Society for Advancement of Cytometry (AU)

• FAPESP's process: 15/19259-0 - Effects of adipose tissue remodeling during cachexia in gastrointestinal cancer patients: potential role of TLR4 receptor during cachexia-induced browning of WAT
• Grantee: Miguel Luiz Batista Junior
• Support Opportunities: Regular Research Grants