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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Peptide Design Enables Reengineering of an Inactive Wasp Venom Peptide into Synthetic Antiplasmodial Agents

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Torres, Marcelo D. T. [1, 2, 3, 4, 5, 6, 7] ; Silva, Adriana F. [1] ; Pedron, Cibele N. [1] ; Capurro, Margareth L. [8] ; de la Fuente-Nunez, Cesar [2, 3, 4, 5, 6, 7] ; Oliveira Junior, Vani X. [1]
Total Authors: 6
[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre, SP - Brazil
[2] Broad Inst MIT & Harvard, Cambridge, MA - USA
[3] MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 - USA
[4] MIT, Dept Elect Engn & Comp Sci, 77 Massachusetts Ave, Cambridge, MA 02139 - USA
[5] Synthet Biol Grp, Cambridge, MA - USA
[6] Res Lab Elect, Belmont, MA - USA
[7] Ctr Microbiome Informat & Therapeut, Cambridge, MA - USA
[8] Univ Sao Paulo, Inst Ciencias Biomed 2, Sao Paulo - Brazil
Total Affiliations: 8
Document type: Journal article
Source: CHEMISTRYSELECT; v. 3, n. 21, p. 5859-5863, JUN 7 2018.
Web of Science Citations: 4

Malaria, caused by Plasmodium protozoa, is responsible for approximate to 0.5 million deaths annually. Decoralin is a wasp-derived peptide with activity against a number of microorganisms but no antiplasmodial function. In its unmodified form, it cannot be used as an anti-infective because of its hemolytic activity. We have generated decoralin analogs with potent antiplasmodial function. Our results provide insight into antiplasmodial sequence requirements and identify single mutations that confer novel biological and therapeutic properties to this peptide, demonstrating the utility of rational peptide design. (AU)

FAPESP's process: 14/04507-5 - Biological applications of new antimicrobial peptides
Grantee:Marcelo Der Torossian Torres
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/12938-6 - Biologically active peptides against pathogenic micro-organisms
Grantee:Vani Xavier de Oliveira Junior
Support type: Regular Research Grants