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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Decreased muscle strength is associated with proinflammatory cytokines but not testosterone levels in men with diabetes

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Ferreira, J. P. [1] ; Leal, A. M. O. [2] ; Vasilceac, F. A. [3] ; Sartor, C. D. [4, 5] ; Sacco, I. C. N. [4] ; Soares, A. S. [1] ; Salvini, T. F. [1]
Total Authors: 7
[1] Univ Fed Sao Carlos, Dept Fisioterapia, Lab Plasticidade Muscular, Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Med, Sao Carlos, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Gerontol, Sao Carlos, SP - Brazil
[4] Univ Sao Paulo, Fac Med, Dept Fisioterapia Fonoaudiol & Terapia Ocupac, Sao Paulo, SP - Brazil
[5] Univ Ibirapuera, Dept Fisioterapia, Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 51, n. 9, p. -, 2018.
Web of Science Citations: 0

The aim of this study was to compare muscle strength in male subjects with type 2 diabetes mellitus (DM2) with and without low plasma testosterone levels and assess the relationship between muscle strength, testosterone levels, and proinflammatory cytokines. Males (75) aged between 18 and 65 years were divided into 3 groups: control group that did not have diabetes and had a normal testosterone plasma level (>250 ng/dL), DnormalTT group that had DM2 with normal testosterone levels, and the DlowTT group that had DM2 and low plasma testosterone levels (<250 ng/dL). The age (means±SD) of the groups was 48.4±10, 52.6±7, and 54.6±7 years, respectively. Isokinetic concentric and isometric torque of knee flexors and extensors were analyzed by an isokinetic dynamometer. Plasma testosterone and proinflammatory cytokine levels were determined by chemiluminescence and ELISA, respectively. Glycemic control was analyzed by glycated hemoglobin (HbA1C). In general, concentric and isometric torques were lower and tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β plasma levels were higher in the groups with diabetes than in controls. There was no correlation between testosterone level and knee torques or proinflammatory cytokines. Concentric and isometric knee flexion and extension torque were negatively correlated with TNF-α, IL-6, and HbA1C. IL-6 and TNF-α were positively correlated with HbA1C. The results of this study demonstrated that muscle strength was not associated with testosterone levels in men with DM2. Low muscle strength was associated with inflammatory markers and poor glycemic control. (AU)

FAPESP's process: 11/22122-5 - Study of the biomechanical, sensorial, cardiorespiratory and quality of life adaptations associated to physical therapy intervention in the fibromyalgic syndrome
Grantee:Tania de Fatima Salvini
Support type: Research Projects - Thematic Grants