| Full text | |
| Author(s): |
Alvarenga, Amanda Botelho
[1]
;
Rovadoscki, Gregori Alberto
[1]
;
Petrini, Juliana
[1]
;
Coutinho, Luiz Lehmann
[1]
;
Morota, Gota
[2]
;
Spangler, Matthew L.
[2]
;
Batista Pinto, Luis Fernando
[3]
;
Pinto Carvalho, Gleidson Giordano
[3]
;
Mourao, Gerson Barreto
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Luiz Queiroz Coll Agr ESALQ, Dept Anim Sci, Piracicaba, SP - Brazil
[2] Univ Nebraska, Dept Anim Sci, Lincoln, NE - USA
[3] Fed Univ Bahia UFBA, Dept Anim Sci, Salvador, BA - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 8, JUN 11 2018. |
| Web of Science Citations: | 3 |
| Abstract | |
For genomic selection to be successful, there must be sufficient linkage disequilibrium between the markers and the causal mutations. The objectives of this study were to evaluate the extent of LD in ovine using the Santa Ines breed and to infer the minimum number of markers required to reach reasonable prediction accuracy. In total, 38,168 SNPs and 395 samples were used. The mean LD between adjacent marker pairs measured by r(2) and vertical bar D'vertical bar were 0.166 and 0.617, respectively. LD values between adjacent marker pairs ranged from 0.135 to 0.194 and from 0.568 to 0.650 for r(2) for vertical bar D'vertical bar across all chromosomes. The average r(2) between all pairwise SNPs on each chromosome was 0.018. SNPs separated by between 0.10 to 0.20 Mb had an estimated average r(2) equal to 0.1033. The identified haplotype blocks consisted of 2 to 21 markers. Moreover, estimates of average coefficients of inbreeding and effective population size were 0.04 and 96, respectively. LD estimated in this study was lower than that reported in other species and was characterized by short haplotype blocks. Our results suggest that the use of a higher density SNP panel is recommended for the implementation of genomic selection in the Santa Ines breed. (AU) | |
| FAPESP's process: | 13/04504-3 - Incorporation of genomic information in the study of carcass and meat quality traits in Santa Inês sheep |
| Grantee: | Gerson Barreto Mourão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/25024-5 - Feed efficiency in sheep Santa Inês in genomic approach |
| Grantee: | Amanda Botelho Alvarenga |
| Support Opportunities: | Scholarships in Brazil - Master |