| Full text | |
| Author(s): Show less - |
Gomes, Nathalia L.
[1]
;
Lerario, Antonio Marcondes
[2, 1]
;
Machado, Aline Zamboni
[1]
;
de Moraes, Daniela Rodrigues
[1]
;
da Silva, Thatiana Evilen
[1]
;
Arnhold, Ivo J. P.
[1]
;
Batista, Rafael Loch
[1]
;
Diniz Faria Junior, Jose Antonio
[1]
;
Costa, Elaine F.
[1]
;
Nishi, Mirian Y.
[1]
;
Inacio, Marlene
[1]
;
Domenice, Sorahia
[1]
;
Mendonca, Berenice B.
[1]
Total Authors: 13
|
| Affiliation: | [1] Univ Sao Paulo, Unidade Endocrinol Desenvolvimento, Disciplina Endocrinol, Lab Hormonios & Genet Mol LIM42, Fac Med, Hosp Clin, Sao Paulo - Brazil
[2] Univ Michigan, Dept Internal Med, Div Metab Endocrinol & Diabet, Ann Arbor, MI 48109 - USA
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | CLINICAL ENDOCRINOLOGY; v. 89, n. 2, p. 164-177, AUG 2018. |
| Web of Science Citations: | 2 |
| Abstract | |
BackgroundFollow-up data on patients with 46,XY partial gonadal dysgenesis (PGD) until adulthood are scarce, making information on prognosis difficult. ObjectiveTo analyse the long-term outcomes of patients with 46,XY PGD regarding testosterone production, germ cell tumour risk, genotype and psychosexual adaptation. MethodsA retrospective longitudinal study of 33 patients (20 assigned male and 13 patients assigned female at birth). Molecular diagnosis was performed by Sanger sequencing or by targeted massively parallel sequencing of 63 genes related to disorders of sex development (DSDs). ResultsAge at first and last visit ranged from 0.1 to 43 and from 17 to 53years, respectively. Spontaneous puberty was observed in 57% of the patients. During follow-up, six of them had a gonadectomy (four due to female gender, and two because of a gonadal tumour). At last evaluation, five of six patients had adult male testosterone levels (median 16.7nmol/L, range 15.3-21.7nmol/L) and elevated LH and FSH levels. Germ cell tumours were found in two postpubertal patients (one with an abdominal gonad and one patient with Frasier syndrome). Molecular diagnosis was possible in 11 patients (33%). NR5A1 variants were the most prevalent molecular defects (n=6), and four of five patients harbouring them developed spontaneous puberty. Gender change was observed in four patients, two from each sex assignment group; all patients reported satisfaction with their gender at final evaluation. Sexual intercourse was reported by 81% of both gender and 82% of them reported satisfaction with their sexual lives. ConclusionSpontaneous puberty was observed in 57% of the patients with 46,XY PGD, being NR5A1 defects the most prevalent ones among all the patients and in those with spontaneous puberty. Gender change due to gender dysphoria was reported by 12% of the patients. All the patients reported satisfaction with their final gender, and most of them with their sexual life. (AU) | |
| FAPESP's process: | 13/02162-8 - Molecular pathogenesis and characterization of monogenic developmental diseases: a route to translational medicine |
| Grantee: | Berenice Bilharinho de Mendonça |
| Support Opportunities: | Research Projects - Thematic Grants |