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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gold-Catalyzed C-S Aryl-Group Transfer in Zinc Finger Proteins

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de Paiva, Raphael E. F. [1, 2] ; Du, Zhifeng [2] ; Nakahata, Douglas H. [1] ; Lima, Frederico A. [3, 4] ; Corbi, Pedro P. [1] ; Farrell, Nicholas P. [2]
Total Authors: 6
[1] Univ Campinas UNICAMP, Inst Chem, POB 6154, BR-13083970 Campinas, SP - Brazil
[2] Virginia Commonwealth Univ, Dept Chem, 1001 W Main St, Richmond, VA 23284 - USA
[3] European XFEL GmbH, Holzkoppel 4, D-22869 Schenefeld - Germany
[4] Brazilian Synchrotron Light Lab LNLS, Ctr Nacl Pesquisa Energia & Mat, BR-13084971 Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION; v. 57, n. 30, p. 9305-9309, JUL 20 2018.
Web of Science Citations: 8

Reaction of the Au-CN chelate {[}Au(bnpy)Cl-2] with the full-length zinc finger (ZnF; ZnCys(3)His) of HIV nucleocapsid protein NCp7 results in C-S aryl transfer from the Au-III organometallic species to a cysteine of the ZnF. The reaction is general and occurs even for finger3 of the transcription factor Sp1, containing a ZnCys(2)His(2) coordination sphere. This reaction is the first demonstration of group transfer from a coordination compound to biologically important zinc fingers, and is especially noteworthy for the ZnCys(2)His(2) transcription factors. The work expands the corpus of organometallic species which can efficiently modify biomolecules through C-atom transfer. The electronic features of the gold compound leading to this unexpected reaction were explored by X-ray absorption spectroscopy. (AU)

FAPESP's process: 15/25114-4 - Synthesis of New Ag(I), Cu(II), Pd(II) and Pt(II) complexes based on sulfonamides and derivatives: antibacterial activities and application prospects on skin critically colonized wounds.
Grantee:Pedro Paulo Corbi
Support type: Regular Research Grants
FAPESP's process: 15/20882-3 - Metal complexes of sulfamethoxydiazine and sulfadimethoxine: synthesis, characterization and applications as antimicrobial agents for topical use
Grantee:Douglas Hideki Nakahata
Support type: Scholarships in Brazil - Doctorate