Protective effects of photobiomodulation against resistance exercise-induced muscle damage and inflammation in rats

Author(s):Show less -

de Oliveira, Helenita Antonia ^[1] ; Antonio, Ednei Luiz ^[2] ; Silva, Flavio Andre ^[2] ; Camillo de Carvalho, Paulo de Tarso ^[1] ; Feliciano, Regiane ^[1] ; Yoshizaki, Amanda ^[2] ; Vieira, Stella de Souza ^[2] ; de Melo, Brunno Lemes ^[2] ; Pinto Leal-Junior, Ernesto Cesar ^[1] ; Labat, Rodrigo ^[3] ; Bocalini, Danilo Sales ^{[4, 5]} ; Silva Junior, Jose Antonio ^[1] ; Ferreira Tucci, Paulo Jose ^[2] ; Serra, Andrey Jorge ^[1]

Affiliation

^[1] Nove Julho Univ, Lab Biophoton, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Sao Paulo - Brazil

^[3] Nove Julho Univ, Postgrad Program Biophoton Appl Hlth Sci, Sao Paulo - Brazil

^[4] Univ Sao Judas Tadeu, Translat Physiol Lab, Sao Paulo - Brazil

^[5] Univ Sao Judas Tadeu, Phys Educ & Aging Sci Program, Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF SPORTS SCIENCES; v. 36, n. 20, p. 2349-2357, 2018.
• Web of Science Citations: 4

Abstract

We investigated whether low-level laser therapy (LLLT) prior to or post resistance exercise could attenuate muscle damage and inflammation. Female Wistar rats were assigned to non-LLLT or LLLT groups. An 830-nm DMC Laser Photon III was used to irradiate their hind legs with 2J, 4J, and 8J doses. Irradiations were performed prior to or post (4J) resistance exercise bouts. Resistance exercise consisted of four maximum load climbs. The load work during a resistance exercise bout was similar between Control (non-LLLT, 225 +/- 10g), 2J (215 +/- 8g), 4J (210 +/- 9g), and 8J (226 +/- 9g) groups. Prior LLLT did not induce climbing performance improvement, but exposure to 4J irradiation resulted in lower blood lactate levels post-exercise. The 4J dose decreased creatine kinase and lactic dehydrogenase levels post-exercise regardless of the time of application. Moreover, 4-J irradiation exposure significantly attenuated tumor necrosis factor alpha, interleukin-6, interleukin-1, cytokine-induced neutrophil chemoattractant-1, and monocyte chemoattractant protein-1. There was minor macrophage muscle infiltration in 4J-exposed rats. These data indicate that LLLT prior to or post resistance exercise can reduce muscle damage and inflammation, resulting in muscle recovery improvement. We attempted to determine an ideal LLLT dose for suitable results, wherein 4J irradiation exposure showed a significant protective role. (AU)

• FAPESP's process: 15/11028-9 - The aerobic training method can determine the existence of cardiac remodeling: structural, functional and molecular analyzes of swimming and running experimental models.
• Grantee: Andrey Jorge Serra
• Support Opportunities: Regular Research Grants