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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Heterocyclic N-oxides - A Promising Class of Agents against Tuberculosis, Malaria and Neglected Tropical Diseases

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Author(s):
dos Santos Fernandes, Guilherme Felipe [1, 2] ; Pavan, Aline Renata [2] ; dos Santos, Jean Leandro [1, 2]
Total Authors: 3
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Chem, Araraquara - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara - Brazil
Total Affiliations: 2
Document type: Review article
Source: CURRENT PHARMACEUTICAL DESIGN; v. 24, n. 12, p. 1325-1340, 2018.
Web of Science Citations: 2
Abstract

Heterocyclic N-oxides have emerged as promising agents against a number of diseases and disorders, especially infectious diseases. This review analyzes the emergence and development of this scaffold in the medicinal chemistry, focusing mainly on the discovery of new heterocyclic N-oxide compounds with potent activity against tuberculosis, malaria and neglected tropical diseases (i.e. leishmaniasis and Chagas disease). A number of heterocyclic N-oxides are described herein, nevertheless, the following chemical classes deserve to be highlighted due to a large number of reports in the literature about their promising pharmacological effects: furoxan, benzofuroxan, quinoxaline 1,4-di-N-oxide, indolone N-oxide and benzimidazole N-oxide. In order to describe those most promising compounds, we included in this review only those most biologically active heterocyclic N-oxide published since 2000. (AU)

FAPESP's process: 15/21252-3 - Synthesis and Pharmacological evaluation of new thalidomide/pomalidomide analogues regulators of epigenetic mechanisms
Grantee:Aline Renata Pavan
Support type: Scholarships in Brazil - Master
FAPESP's process: 16/09502-7 - Design, synthesis and antitubercular activity of new oxazolidinones useful for the treatment of multidrug-resistant tuberculosis
Grantee:Guilherme Felipe dos Santos Fernandes
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/19531-1 - Targeting histone deacetylase (HDAC-1 and HDAC-2) as mechanisms to induce fetal hemoglobin in sickle cell disease
Grantee:Jean Leandro dos Santos
Support type: Regular Research Grants