Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Heterocyclic N-oxides - A Promising Class of Agents against Tuberculosis, Malaria and Neglected Tropical Diseases

Full text
Author(s):
dos Santos Fernandes, Guilherme Felipe [1, 2] ; Pavan, Aline Renata [2] ; dos Santos, Jean Leandro [1, 2]
Total Authors: 3
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Chem, Araraquara - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara - Brazil
Total Affiliations: 2
Document type: Review article
Source: CURRENT PHARMACEUTICAL DESIGN; v. 24, n. 12, p. 1325-1340, 2018.
Web of Science Citations: 2
Abstract

Heterocyclic N-oxides have emerged as promising agents against a number of diseases and disorders, especially infectious diseases. This review analyzes the emergence and development of this scaffold in the medicinal chemistry, focusing mainly on the discovery of new heterocyclic N-oxide compounds with potent activity against tuberculosis, malaria and neglected tropical diseases (i.e. leishmaniasis and Chagas disease). A number of heterocyclic N-oxides are described herein, nevertheless, the following chemical classes deserve to be highlighted due to a large number of reports in the literature about their promising pharmacological effects: furoxan, benzofuroxan, quinoxaline 1,4-di-N-oxide, indolone N-oxide and benzimidazole N-oxide. In order to describe those most promising compounds, we included in this review only those most biologically active heterocyclic N-oxide published since 2000. (AU)

FAPESP's process: 15/21252-3 - Synthesis and Pharmacological evaluation of new thalidomide/pomalidomide analogues regulators of epigenetic mechanisms
Grantee:Aline Renata Pavan
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 16/09502-7 - Design, synthesis and antitubercular activity of new oxazolidinones useful for the treatment of multidrug-resistant tuberculosis
Grantee:Guilherme Felipe dos Santos Fernandes
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/19531-1 - Targeting histone deacetylase (HDAC-1 and HDAC-2) as mechanisms to induce fetal hemoglobin in sickle cell disease
Grantee:Jean Leandro dos Santos
Support Opportunities: Regular Research Grants