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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The role of the baroreflex and parasympathetic nervous system in fructose-induced cardiac and metabolic alterations

Full text
Author(s):
dos Santos, Fernando [1] ; Moraes-Silva, Ivana C. [1] ; Moreira, Edson D. [1] ; Irigoyen, Maria-Claudia [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo FMUSP, Sch Med, Heart Inst InCor, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, JUL 20 2018.
Web of Science Citations: 2
Abstract

It is well-established that baroreflex sensitivity is essential for blood pressure control, and also plays a key role in the modulation of disease-induced metabolic alterations. In order to investigate the role of the baroreflex in the cardiometabolic and inflammatory derangements promoted by fructose overload, Wistar rats underwent sinoaortic denervation (SAD) or sham surgery and were studied 90 days after receiving tap water (Den and Ctrl) or a 10% fructose solution (Fruc and Den-Fruc). All experimental groups showed marked and similar degree of baroreflex impairment compared to Ctrl. As expected, fructose overload effectively induced metabolic syndrome; however, when it was associated with SAD, several alterations were attenuated. While Fruc rats displayed increased sympathetic modulation and tone and reduced vagal modulation compared to Ctrl animals, Den-Fruc rats showed greater vagal tone and modulation when compared to the Fruc group. Moreover, the Den-Fruc group showed augmented expression of beta 1 adrenergic receptors and TNF/IL-10 ratio and reduction of beta 2 in the left ventricle. The increase in vagal function was correlated with improved insulin sensitivity (r(2)= 0.76), and decreased abdominal fat (r(2)= -0.78) and beta 2 receptors (r(2) = -0.85). Our results showed that: (1) chronic fructose overload induced severe baroreflex impairment, i.e. in a similar magnitude to that observed in SAD rats, which is accompanied by cardiometabolic dysfunctions; (2) the compensatory enhancement in parasympathetic function in SAD rats submitted to fructose intake may point out the possibility of use of approaches that improve vagal function as therapeutic target to attenuate fructose-induced cardiometabolic dysfunctions. (AU)

FAPESP's process: 13/23418-0 - Role of baroreflex in the time course of autonomic and metabolic alterations of fructose-overload hypertension
Grantee:Fernando dos Santos
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 11/04111-6 - Role of baroreflex in the time course of autonomic and metabolic alterations of fructose-overload hypertension
Grantee:Fernando dos Santos
Support Opportunities: Scholarships in Brazil - Master