Isolated vitamin D supplementation improves the immune-inflammatory biomarkers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial

Author(s)

Bueloni-Dias, Flavia Neves ^[1] ; Orsatti, Claudio Lera ^[1] ; Cangussu, Luciana Mendes ^[1] ; Poloni, Priscila Ferreira ^[1] ; Spadoto-Dias, Daniel ^[1] ; Nahas-Neto, Jorge ^[1] ; Nahas, Eliana A. P. ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Gynecol & Obstet, Dist Rubiao Jr S-N, BR-18618970 Botucatu, SP - Brazil

• Document type: Journal article
• Source: MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY; v. 25, n. 8, p. 897-903, AUG 2018.
• Web of Science Citations: 3

Abstract

Objective:The aim of this study was to evaluate the effect of vitamin D (VitD) supplementation on immune-inflammatory biomarkers in younger postmenopausal women.Methods:In this double-blind, placebo-controlled trial, 160 postmenopausal women aged 50 to 65 years with amenorrhea 12 months were randomized into two groups: VitD group, oral supplementation with 1000IU VitD(3)/day (n=80) or placebo group (n=80). The intervention time was 9 months, and the women were assessed at baseline and endpoint. Serum levels of interleukins (ILs)-1, IL-5, IL-6, IL-10, IL-1270, IL-17, tumor necrosis factor-alpha, and interferon-gamma were determined by immunoassay. Plasma concentrations of 25-hydroxyvitamin D {[}25(OH)D] were measured by high-performance liquid chromatography. Per-protocol analysis was adopted as the statistical method using a gamma distribution and repeated measures design, followed by Wald's multiple comparisons test.Results:The two groups were similar at baseline in terms of clinical and laboratory parameters. After 9 months, there was a significant increase of 25(OH)D levels in the VitD group (+45.4%, P<0.001) and a decrease (-18.5%, P=0.049) in the placebo group. A significant decrease in IL-5, IL-12p70, IL-17, tumor necrosis factor-alpha, and interferon-gamma levels was observed in the VitD group (P<0.05). IL-5 and IL-6 levels were significantly lower in the VitD group compared to the placebo group (P<0.05). There were no significant intervention effects on serum IL-1 or IL-10 levels in either group (P>0.05).Conclusions:In younger postmenopausal women, isolated supplementation with 1000IU of VitD(3) for 9 months was associated with a reduction in proinflammatory biomarkers. (AU)

• FAPESP's process: 14/19382-3 - The role of vitamin D on cardiometabolic and immuno-inflammatory profile of postmenopausal women
• Grantee: Eliana Aguiar Petri Nahás
• Support Opportunities: Regular Research Grants