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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Brain parenchymal changes during normal aging in domestic cats

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Author(s):
Babicsak, Viviam R. [1] ; Klein, V, Adriana ; Tsunemi, Miriam H. [2] ; Vulcano, Luiz C. [3]
Total Authors: 4
Affiliation:
[1] Univ Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Dept Reprod Anim & Radiol Vet, Campus Botucatu, BR-18618681 Botucatu, SP - Brazil
[2] UNESP, Dept Bioestatist, Inst Biociencias, Campus Botucatu, BR-18618681 Botucatu, SP - Brazil
[3] Klein, Adriana, V, Univ Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Dept Reprod Anim & Radiol Vet, Campus Botucatu, BR-18618681 Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 38, n. 6, p. 1196-1202, JUN 2018.
Web of Science Citations: 0
Abstract

ABSTRACT: This study aimed to identify changes related to brain parenchyma as advancing age in healthy domestic cats. Our hypothesis is that cats suffer cerebral and cerebellar atrophy and show focal changes in signal intensity of the brain parenchyma in accordance with the progression of age. Twelve adult (1 to 6 years), eleven mature (7 to11 years) and ten geriatric non-brachycephalic cats (12 years or more of age) underwent brain magnetic resonance imaging (MRI). There were no changes in signal intensity and contrast uptake in brain parenchyma of the cats. Geriatric animals showed significantly lower average thickness of the interthalamic adhesion and percentage of the cerebral parenchyma volume in relation to intracranial volume than those found in the adult group. No significant differences were found between groups for cerebral volume, cerebellar volume and percentage of cerebellar volume in relation to intracranial volume. The results of this study indicate that atrophy of the cerebral parenchyma, including the interthalamic adhesion, occurs with age in domestic cats, confirming the hypothesis of the study. However, the results did not corroborate the hypothesis that cats show cerebellar atrophy and focal changes in signal intensity of the brain parenchyma with advancing age. (AU)

FAPESP's process: 13/06148-0 - Encephalic study of adults and elderly domestic cats by magnetic resonance imaging
Grantee:Luiz Carlos Vulcano
Support Opportunities: Regular Research Grants
FAPESP's process: 12/18750-3 - ENCEPHALIC STUDY OF ADULT, MATURE AND GERIATRIC DOMESTIC CATS BY MAGNETIC RESONANCE IMAGING
Grantee:Viviam Rocco Babicsak
Support Opportunities: Scholarships in Brazil - Doctorate