Association between adiposity and systemic atherosclerosis: a protocol of a cross-sectional autopsy study

Author(s):Show less -

Nishizawa, Aline ^{[1, 2]} ; Suemoto, Claudia Kimie ^{[1, 3, 2]} ; Farias, Daniela Souza ^{[1, 2]} ; Campos, Fernanda Marinho ^[2] ; Souza da Silva, Karen Cristina ^{[1, 2]} ; Cuelho, Anderson ^{[1, 2]} ; Paraizo Leite, Renata Elaine ^{[1, 3]} ; de Lucena Ferretti-Rebustini, Renata Eloah ^{[4, 1]} ; Grinberg, Lea Tenenholz ^{[5, 1]} ; Farfel, Jose Marcelo ^{[1, 3]} ; Jacob-Filho, Wilson ^{[1, 3]} ; Pasqualucci, Carlos Augusto ^{[6, 1, 2]}

Affiliation

^[1] Univ Sao Paulo, Sch Med, Pathophysiol Aging Lab, Brazilian Aging Brain Study Grp LIM 22, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Pathol, Lab Cardiovasc Pathol LIM 22, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Sch Med, Discipline Geriatr, Dr Arnaldo Ave 455, Room 1353, BR-01246903 Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Sch Nursing, Sao Paulo, SP - Brazil

^[5] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA - USA

^[6] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: OPEN HEART; v. 3, n. 2 AUG 2016.
• Web of Science Citations: 4

Abstract

Introduction: Adiposity has been associated with atherosclerosis in clinical studies. However, few autopsy studies have investigated this association, and they had only examined the coronary artery disease. Moreover, most studies had small sample sizes and were limited to middle-aged or young adults. Our aim is to investigate the association between adiposity and systemic atherosclerosis in an autopsy study. Methods and analysis: A sample of 240 deceased with 30 years or more will be evaluated. The sample size was calculated using the lowest correlation coefficient found in previous studies (r=0.109), assuming a power of 90% and alpha=0.05. We will collect information about sociodemographics, frequency of previous contact of the deceased's next of kin and cardiovascular risk factors. We will measure neck, waist and hip circumferences, weight, height and abdominal subcutaneous tissue thickness, and then we will calculate the body mass index, waist-to-hip ratio, waist-to-height ratio and body shape index. We will also weigh the pericardial and abdominal visceral fat, the heart, and we will measure the left ventricular wall thickness. We will evaluate the presence of myocardial infarction, the degree of atherosclerosis in the aorta, carotid, coronary and cerebral arteries and plaque composition in carotid, coronary and cerebral arteries. For each individual, we will fix arterial and adipose tissue samples in 10% formalin and freeze another adipose tissue sample at -80 degrees C for future studies. Ethics and dissemination: Ethical approval was granted by the Ethics Committee of University of Sao Paulo Medical School, Brazil. Results will be submitted for publication in a peer-reviewed journal. (AU)

• FAPESP's process: 13/12290-3 - ASSOCIATION BETWEEN EPICARDIAL ADIPOSE TISSUE INFLAMMATION AND CORONARY ARTERY DISEASE: A CLINICOPATHOLOGICAL STUDY
• Grantee: Daniela Souza Farias Itao
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 12/25337-5 - Association between visceral abdominal fat and dementia
• Grantee: Anderson Cuelho
• Support Opportunities: Scholarships in Brazil - Scientific Initiation