Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pandemic non-adjuvanted influenza A H1N1 vaccine in a cohort of patients with systemic sclerosis

Full text
Author(s):
Sampaio-Barros, Percival D. [1]
Total Authors: 1
Affiliation:
[1] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Div Rheumatol, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: RHEUMATOLOGY; v. 57, n. 10, p. 1721-1725, OCT 2018.
Web of Science Citations: 2
Abstract

Objective. To assess the possible effect of therapy, disease subtype and severity on H1N1 immunogenicity in patients with SSc. Methods. Ninety-two patients and 92 age- and gender-matched healthy controls received adjuvant-free influenza A/California/7/2009 (pH1N1) vaccine. Blood samples were collected immediately before and 3 weeks after vaccination to evaluate antibody responses to the H1N1 virus. Efficacy was assessed by seroprotection (SP) and seroconversion (SC) rates and the factor increase in geometric mean antibody titre. Participants received a 21-day symptom diary card and were instructed to report local and systemic adverse events. Results. SSc patients were predominantly females (91 %) and 61 % had limited SSc, 12% had severe skin involvement and 57.6% were on immunosuppressive (IS) therapy. SSc patients and controls presented comparable overall SP (P=0.20) and SC (P=0.61) rates. Further evaluation of the possible effect of disease and therapy revealed similar rates of SP and SC in patients with dcSSc vs IcSSc (SP P =0.62 and SC P = 0.66), severe vs mild/moderate skin involvement (SP P=1 and SC P = 0.45) and with vs without IS (SP P = 0.26 and SC P=0.10). The frequency of mild local and minor systemic reactions was similar in patients with dcSSC vs IcSSc (P =0.70 vs 0.32) and in those with and without severe skin involvement (P = 0.59 vs 0.28). Conclusion. The non-adjuvanted influenza H1N1 virus vaccine proved to be safe and effective, independent of SSc clinical subtype, disease severity or therapy. These latter factors do not seem to contribute to mild adverse events observed in SSc. Our data support the annual influenza vaccination recommendation for these patients. (AU)

FAPESP's process: 10/10749-0 - Anti-influenza H1N1/2009 vaccine in autoimmune rheumatic diseases patients
Grantee:Eloisa Silva Dutra de Oliveira Bonfá
Support Opportunities: Regular Research Grants