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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ARHGAP21 as a master regulator of multiple cellular processes

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Rosa, Lucas R. O. [1] ; Soares, Gabriela M. [1] ; Silveira, Leonardo R. [1] ; Boschero, Antonio C. [1] ; Barbosa-Sampaio, Helena C. L. [1]
Total Authors: 5
[1] Univ Campinas UNICAMP, Inst Biol, OCRC, Dept Struct & Funct Biol, Carl Von Linaeus, 2-238Cidade Univ, Campinas, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: Journal of Cellular Physiology; v. 233, n. 11, p. 8477-8481, NOV 2018.
Web of Science Citations: 2

The cellular cytoskeleton is involved with multiple biological processes and is tightly regulated by multiple proteins and effectors. Among these, the RhoGTPases family is one of the most important players. RhoGTPAses are, in turn, regulated by many other elements. In the past decade, one of those regulators, the RhoGAP Rho GTPase Activating Protein 21 (ARHGAP21), has been overlooked, despite being implied as having an important role on many of those processes. In this paper, we aimed to review the available literature regarding ARHGAP21 to highlight its importance and the mechanisms of action that have been found so far for this still unknown protein involved with cell adhesion, migration, Golgi regulation, cell trafficking, and even insulin secretion. (AU)

FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 15/12611-0 - Molecular mechanisms involved in pancreatic beta cell disfunction and dead in diabetes mellitus: strategies for the inhibition of these processes and restoration of the insular mass
Grantee:Antonio Carlos Boschiero
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/14993-9 - Type 3 muscarinic receptor activation and association with ADP-rybosilation factor 1 and 6 on the pancreatic beta-cell function: downstream signalling pathways, islet arquitecture and insulin secretion
Grantee:Helena Cristina de Lima Barbosa Sampaio
Support type: Research Grants - Young Investigators Grants