The Ambiguous Roles of Extracellular Vesicles in HIV Replication and Pathogenesis

Author(s)

dasilva, Luis L. P. ^[3]

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Ctr Virus Res, Ribeirao Preto - Brazil

• Document type: Review article
• Source: FRONTIERS IN MICROBIOLOGY; v. 9, OCT 10 2018.
• Web of Science Citations: 5

Abstract

Cells from all kingdoms of life can release membrane-enclosed vesicles to the extracellular milieu. These extracellular vesicles (EVs) may function as mediators of intercellular communication, allowing the transfer of biologically active molecules between cells and organisms. It has become clear that HIV particles and certain types of EVs, such as exosomes, share many similarities regarding morphology, composition, and biogenesis. This review presents a summary of the literature describing the intricate relationship between HIV and EVs biogenesis. Also, we discuss the latest progress toward understanding the mechanisms by which EVs influence HIV pathogenesis, as well as, how HIV modulates EVs composition in infected cells to facilitate viral spread. (AU)

• FAPESP's process: 14/02438-6 - Studies with Bunyaviridae that produce human disease
• Grantee: Luiz Tadeu Moraes Figueiredo
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/00297-7 - Study of the effects of HIV-1 Nef on the host-cell endomembrane system and their implications in viral pathogenesis
• Grantee: Luis Lamberti Pinto da Silva
• Support Opportunities: Regular Research Grants