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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Venomous caterpillars: From inoculation apparatus to venom composition and envenomation

Full text
Author(s):
Villas-Boas, Isadora Maria [1] ; Bonfa, Giuliano [1] ; Tambourgi, Denise V. [1]
Total Authors: 3
Affiliation:
[1] Butantan Inst, Immunochem Lab, Ave Vital Brazil 1500, BR-05503900 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Toxicon; v. 153, p. 39-52, OCT 2018.
Web of Science Citations: 3
Abstract

Envenomation by the larval or pupal stages of moths occurs when the victim presses their hairs. They penetrate the subcutaneous tissue, releasing toxins such as proteolytic enzymes, histamine and other pro-inflammatory substances. Cutaneous reactions, including severe pain, oedema and erythema are frequent local manifestations of caterpillar envenomation, but, in some cases, the reactions can evolve into vesicles, bullae, erosions, petechiae, superficial skin necrosis and ulcerations. Alternatively, some individual can develop allergic reactions, renal failure, osteochondritis, deformity and immobilization of the affected joints and intracerebral bleeding. Caterpillars produce venom to protect themselves from predators; contact with humans is accidental and deserves close attention. Their venoms have not been well studied, except for toxins from some few species. The present review brings together data on venomous caterpillars of moths, primarily addressing the available literature on diversity among the different families that cause accident in humans, the structures used in their defense, venom composition and clinical aspects of the envenomations. Understanding the molecular mechanisms of action of caterpillars' toxins may lead to the development of more adequate treatments. (AU)

FAPESP's process: 15/50040-4 - Rational approach for searching molecular targets involved in inflammatory events and cell survival
Grantee:Ana Marisa Chudzinski-Tavassi
Support type: Research Grants - Research Centers in Engineering Program
FAPESP's process: 13/50158-0 - Evaluation of bristles extract effects of Premolis semirufa, etiologic agent of pararamose, on human chondrocytes
Grantee:Isadora Maria Villas Boas Silva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/07009-4 - Signaling pathways involved in inflammatory response in osteoarthritis 3D culture models
Grantee:Giuliano Bonfá
Support type: Scholarships in Brazil - Post-Doctorate