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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development of a simple electrochemical sensor for the simultaneous detection of anticancer drugs

Full text
Author(s):
Materon, Elsa Maria [1] ; Wong, Ademar [1] ; Fatibello-Filho, Orlando [1] ; Faria, Ronaldo Censi [1]
Total Authors: 4
Affiliation:
[1] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 827, p. 64-72, OCT 15 2018.
Web of Science Citations: 6
Abstract

The most used drug cocktail for the treatment of metastatic or advanced types of cancers is the combination of Doxorubicin (DOX) and Methotrexate (MTX). On one hand, in the chemotherapy, it is crucially important to detect and maintain a good concentration of the anticancer drugs in the patient's body, in order to prevent serious side effects of the drugs. Whereas, on the other hand, these drugs are excreted in faeces and urine from the patient and can contaminate the aquatic environments, which may cause several health hazards. In view of that, an electrochemical sensor was proposed for the simultaneous determination of DOX and MTX using carbon black (CB), cooper nanoparticles (CuNPs), and Nafion modified glassy carbon electrode. Morphological and chemical characterization of these materials was performed using FEG-SEM images and EDS analysis. The modified electrode exhibited good catalytic activity for electrochemical oxidation in square wave voltammetry, with redox potential of 0.69 V and 0.93 V for DOX and MTX, respectively. Under optimized conditions, linear response range of 4.5 x 10(-7) to 5.1 x 10(-6) mol L-1 and 2.2 x 10(-6) to 2.5 x 10(-5) mol L-1 with limit of detection of 2.4 x 10(-8) mol L-1 and 9.0 x 10(-8) mol L-1 were achieved for DOX and MTX, respectively. Finally the CuNPs-CB-Nafion/GCE sensor was successfully applied toward the determination of DOX and MTX in biological matrix (human urine samples) and within the environment (water river samples), where a spike recovers of nearly 100% was obtained. (AU)

FAPESP's process: 15/19890-1 - Development of methods for diagnosis of diseases using magnetic particles and an array of imunossensors in a disposable microfluidic system
Grantee:Ronaldo Censi Faria
Support Opportunities: Regular Research Grants