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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction?

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Author(s):
Trevisan, Camila M. [1] ; Montagna, Erik [2] ; de Oliveira, Renato [1] ; Christofolini, Denise M. [1] ; Barbosa, Caio P. [1] ; Crandall, Keith A. [3] ; Bianco, Bianca [1]
Total Authors: 7
Affiliation:
[1] Fac Med ABC, Human Reprod & Genet Ctr, Dept Collect Hlth, Santo Andre - Brazil
[2] Fac Med ABC, Div Post Grad, Santo Andre - Brazil
[3] George Washington Univ, Computat Biol Inst, Milken Inst Sch Publ Hlth, Washington, DC - USA
Total Affiliations: 3
Document type: Review article
Source: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; v. 49, n. 4, p. 1259-1276, 2018.
Web of Science Citations: 7
Abstract

Kisspeptin is involved in the control of human reproduction bridging the gap between the sex steroid levels and feedback mechanisms that control the gonadotropin releasing hormone (GnRH) secretion; however, studies considering this peptide and infertility are limited. We conducted a review and critical assessment of available evidence considering kisspeptin structure, physiology, function in puberty and reproduction, its role in assisted reproduction treatments, kisspeptin dosage and the impact on KISS1 and GPR54 genes. Literature searches were conducted in PubMed using keywords related to: (i) kisspeptin or receptors, kisspeptin-1 (ii) reproduction or infertility or fertility (iii) gene and (iv) dosage or measurement or quantification or serum level, in human. Kisspeptin is a product of KISS1 gene that binds to a G-protein-coupled receptor (GPR54/KISS1R) stimulating the release of GnRH by hypothalamic neurons, leading to secretion of pituitary gonadotropins (LH and FSH) and sexual steroids, which in turn will act in the gonads to produce the gametes. Kisspeptin is being recognized as a crucial regulator of the onset of puberty, the regulation of sex hormone mediated secretion of gonadotropins, and the control of fertility. Inactivating and activating mutations in both KISS1 or GPR54 genes were associated with hypogonadotropic hypogonadism and precocious puberty. Despite this, studies considering kisspeptin and infertility are scarce. The understanding of the role of kisspeptin may lead to its use as a biomarker in infertility treatments and use in controlled ovarian hyperstimulation. (C) 2018 The Author(s) Published by S. Karger AG, Basel (AU)

FAPESP's process: 16/25953-9 - Evaluation of mutations and/or polymorphisms in candidate genes by next generation sequence in infertile women with and without endometriosis and its correlation with results of controlled ovarian hyperstimulation in assisted human reproduction treatments
Grantee:Bianca Alves Vieira Bianco
Support Opportunities: Regular Research Grants