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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2)

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Author(s):
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Bittencourt, Najara C. [1] ; Leite, Juliana A. [1] ; Silva, Ana Beatriz I. E. [2] ; Pimenta, Tamirys S. [3] ; Silva-Filho, Joao Luiz [1] ; Cassiano, Gustavo C. [1] ; Lopes, Stefanie C. P. [4, 5] ; dos-Santos, Joao C. K. [1] ; Bourgard, Catarina [1] ; Nakaya, Helder I. [6] ; Revoredo da Silva Ventura, Ana Maria [3] ; Lacerda, Marcus V. G. [4, 5] ; Ferreira, Marcelo U. [7] ; Machado, Ricardo L. D. [3] ; Albrecht, Letusa [2] ; Costa, Fabio T. M. [1]
Total Authors: 16
Affiliation:
[1] Univ Campinas UNICAMP, Dept Genet Evolut Microbiol & Immunol, Lab Trop Dis Prof Dr Luiz Jacintho da Silva, Campinas, SP - Brazil
[2] Fiocruz MS, Fundacao Oswaldo Cruz, Inst Carlos Chagas, Curitiba, PR - Brazil
[3] Inst Evandro Chagas SVS MS, Lab Ensaios Clin & Imunogenet Malaria, Ananindeua, PA - Brazil
[4] Fiocruz MS, Fundacao Oswaldo Cruz, Inst Leonidas & Maria Deane, Manaus, AM - Brazil
[5] Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, AM - Brazil
[6] Univ Sao Paulo, Sch Pharmaceut Sci, Sao Paulo - Brazil
[7] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Malaria Journal; v. 17, OCT 31 2018.
Web of Science Citations: 1
Abstract

BackgroundThe genetic diversity of malaria antigens often results in allele variant-specific immunity, imposing a great challenge to vaccine development. Rhoptry Neck Protein 2 (PvRON2) is a blood-stage antigen that plays a key role during the erythrocyte invasion of Plasmodium vivax. This study investigatesthe genetic diversity of PvRON2 and the naturally acquired immune response to P. vivax isolates.ResultsHere, the genetic diversity of PvRON2(1828-2080) and the naturally acquired humoral immune response against PvRON2(1828-2080) in infected and non-infected individuals from a vivax malaria endemic area in Brazil was reported. The diversity analysis of PvRON2(1828-2080) revealed that the protein is conserved in isolates in Brazil and worldwide. A total of 18 (19%) patients had IgG antibodies to PvRON2(1828-2080). Additionally, the analysis of the antibody response in individuals who were not acutely infected with malaria, but had been infected with malaria in the past indicated that 32 patients (33%) exhibited an IgG immune response against PvRON2.ConclusionsPvRON2 was conserved among the studied isolates. The presence of naturally acquired antibodies to this protein in the absence of the disease suggests that PvRON2 induces a long-term antibody response. These results indicate that PvRON2 is a potential malaria vaccine candidate. (AU)

FAPESP's process: 13/20509-5 - Analyses of the immunopathological and molecular mechanisms involved in cytoadherence of Plasmodium vivax
Grantee:Catarina Baeta da Luz Bourgard
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/02808-0 - Genetic diversity and immunogenicity of MAEBL amongst Plasmodium vivax field isolates
Grantee:Najara Carneiro Bittencourt
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 15/20774-6 - Identifying protein kinase inhibitors as antimalarial agents using chemogenomic, bioinfomatics and phenotypic strategies: focus in Plasmodium vivax.
Grantee:Gustavo Capatti Cassiano
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 12/16525-2 - Plasmodium vivax: pathogenesis and infectivity
Grantee:Fabio Trindade Maranhão Costa
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/25807-4 - Dissecting the mechanisms of infectivity in Plasmodium - Plasmodium yoelii experimental model with implications for the study in Plasmodium vivax.
Grantee:Juliana Almeida Leite
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/12855-9 - Mechanism of action of lipoxin in the protection against experimental cerebral malaria
Grantee:João Luiz da Silva Filho
Support Opportunities: Scholarships in Brazil - Post-Doctoral