Potentially Malignant Oral Disorders and Cancer Transformation

Author(s)

Ganesh, Divya ^[1] ; Sreenivasan, Prathima ^[2] ; Ohman, Jenny ^[1] ; Wallstrom, Mats ^[3] ; Braz-Silva, Paulo Henrique ^{[4, 5]} ; Giglio, Daniel ^[6] ; Kjeller, Goran ^[3] ; Hasseus, Bengt ^[1]

Affiliation

^[1] Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral Med & Pathol, Gothenburg - Sweden

^[2] Kannur Dent Coll, Dept Oral Med, Anjarakandy, Kerala - India

^[3] Univ Gothenburg, Sahlgrenska Acad, Inst Odontol, Dept Oral & Maxillofacial Surg, Gothenburg - Sweden

^[4] Univ Sao Paulo, Sch Dent, Dept Stomatol, Div Gen Pathol, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Inst Trop Med Sao Paulo, Virol Lab, Sao Paulo - Brazil

^[6] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Oncol, Gothenburg - Sweden

• Document type: Review article
• Source: ANTICANCER RESEARCH; v. 38, n. 6, p. 3223-3229, JUN 2018.
• Web of Science Citations: 5

Abstract

Cancer in the oral cavity is often preceded by precursor lesions. Nine oral mucosal disorders are known to have an increased risk of malignant transformation. The etiology varies from disorders caused by exogenous factors such as tobacco and autoimmune inflammation to idiopathic or inherited genetic aberrations. In this review, these potentially malignant disorders (PMDs) are described regarding clinical presentation and histopathological architecture. Special attention is paid to the underlying etiologies of PMDs and the potential pathways leading to cancer. The clinical perspective focuses on the importance of accurate and timely diagnosis. (AU)

• FAPESP's process: 15/07727-9 - Evaluation of immunoregulatory microenvironment of oral premalignant lesions, squamous cell carcinomas and oropharyngeal carcinomas related to HPV or not.
• Grantee: Paulo Henrique Braz da Silva
• Support Opportunities: Regular Research Grants