Circulating levels of tissue factor and the risk of thrombosis associated with antiphospholipid syndrome

Author(s)

Tobaldini, Lais Quinteiro ^[1] ; Arantes, Fernanda Talge ^[1] ; Saraiva, Sabrina da Silva ^[1] ; Mazetto, Bruna de Moraes ^[1] ; Colella, Marina Pereira ^[1] ; de Paula, Erich Vinicius ^[2] ; Annichino-Bizzachi, Joyce ^[2] ; Orsi, Fernanda Andrade ^{[1, 3]}

Affiliation

^[1] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Fac Med Sci, Dept Clin Med, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Fac Med Sci, Dept Clin Pathol, R Tessalia Vieira Camargo 126, Cidade Univ, BR-13083887 Campinas, SP - Brazil

• Document type: Journal article
• Source: THROMBOSIS RESEARCH; v. 171, p. 114-120, NOV 2018.
• Web of Science Citations: 2

Abstract

The mechanisms behind the severe hypercoagulable state in antiphospholipid syndrome (APS) have not yet been fully elucidated. Knowledge on the etiology of thrombosis in APS is needed to improve treatment. We performed a case control study to evaluate the association of the levels of circulating tissue factor (TF) with thrombotic APS and unprovoked venous thromboembolism (VTE), as compared with controls without a history of thrombosis. Study participants were selected in the same geographic area. Linear regression was used to evaluate possible determinants of TF levels among controls and logistic regression was used to evaluate the association between TF, unprovoked VTE and t-APS. TF levels were grouped into three categories based on: below 50th percentile {[}reference], between 50-75th percentiles {[}second category] and 75th percentile {[}third category]. Two hundred and eighty participants were included in the study; 51 patients with unprovoked VTE, 111 patients with t-APS and 118 control individuals. The levels of TF were not associated with an increased risk of unprovoked VTE, as compared with controls. The adjusted odds ratio for t-APS was 2.62 (95%CI 1.03 to 6.62) with TF levels between 50-75th percentiles and 8.62 (95%CI 3.76 to 19.80) with TF levels above the 75th percentile, as compared with the reference category (below the 50th percentile). In the subgroup analysis, higher levels of TF were associated with both arterial and venous thrombosis in APS and with both primary and secondary APS. Circulating TF is associated with thrombotic complications related to APS, but not with the risk of unprovoked VTE. (AU)

• FAPESP's process: 16/14172-6 - Investigation of the pathophysiological aspects and novel therapeutic approaches for thromboembolic disorders
• Grantee: Joyce Maria Annichino-Bizzacchi
• Support Opportunities: Research Projects - Thematic Grants