Effect of a constant rate infusion of remifentanil hydrochloride on left ventricular systolic and diastolic function in propofol-anesthetized dogs

Author(s)

Marques, Marcel G. ^[1] ; Cancelli, Carlos H. B. ^[1] ; Fernandes, Carollina M. S. ^[1] ; Games, Bruna M. M. ^[1] ; Floriano, Beatriz P. ^[1] ; Perri, Silvia H. V. ^[1] ; Sousa, Marlos G. ^[1] ; Ferreira, Wagner L. ^[1] ; Santos, Paulo S. P. ^[1]

Affiliation

^[1] Sao Paulo State Univ, Dept Anim Clin Surg & Reprod, Fac Vet Med, BR-16050680 Aracatuba - Brazil

• Document type: Journal article
• Source: AMERICAN JOURNAL OF VETERINARY RESEARCH; v. 79, n. 12, p. 1261-1267, DEC 2018.
• Web of Science Citations: 0

Abstract

OBJECTIVE To assess the effects of a constant rate infusion (CRI) of remifentanil hydrochloride on left ventricular systolic and diastolic function in healthy propofol-anesthetized dogs. ANIMALS 6 healthy Beagles. PROCEDURES Each dog underwent 2 experimental treatments separated by a 7-day interval. In 1 treatment, anesthesia was induced with propofol and maintained with a CRI of propofol (0.6 mg/kg/min); dogs also received a CRI of saline (0.9% NaCl) solution. In the other treatment, anesthesia was similarly induced and maintained with propofol; dogs also received a CRI of remifentanil (0.3 mu g/kg/min). Doppler echocardiographic and hemodynamic variables of interest were determined at baseline (before anesthesia) and at 20, 40, and 60 minutes following the simultaneous start of the 2 CRIs of each treatment; all CRIs were administrated for 60 minutes. RESULTS For the 2 treatments, end-diastolic and end-systolic volume indices did not differ from baseline or at any time point. Peak tissue Doppler-derived mitral annulus systolic velocity decreased from baseline with both treatments; however, no differences were found between treatments at any time point. Mean arterial blood pressure decreased similarly with both treatments. Heart rate and Doppler-determined cardiac index decreased significantly with the propofol-remifentanil treatment, compared with findings for the propofol-saline solution treatment. For the propofol-remifentanil treatment, the ratio of peak velocity flow in early diastole to that in late diastole remained > 1.80, whereas the ratio of early to late Doppler-derived mitral annulus velocity had a normal relaxation pattern. CONCLUSIONS AND CLINICAL RELEVANCE Results of this study indicated that a CRI of remifentanil administered along with a CRI of propofol does not impair left ventricular systolic and diastolic function in healthy dogs. (AU)

• FAPESP's process: 15/01806-4 - Echocardiographic evaluation in dogs submitted to continuous infusion of propofol associated or not to remifentanil
• Grantee: Marcel Gambin Marques
• Support Opportunities: Scholarships in Brazil - Master